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rash

› Forums › General Melanoma Community › rash

  • Post
    • June 9, 2013 at 8:42 pm
    Wolfie
    Participant

      Severe body rash after5 days on full dose Zelboraf. Stopped x 1week, resumed half dose. Rash continued, low grade temp., swollen knuckles. Had to stop again. Anyone had similar experience? Able to stay on Zelboraf? Anyone try prednisone or other treatment? Thanks in advance, Jean

      Severe body rash after5 days on full dose Zelboraf. Stopped x 1week, resumed half dose. Rash continued, low grade temp., swollen knuckles. Had to stop again. Anyone had similar experience? Able to stay on Zelboraf? Anyone try prednisone or other treatment? Thanks in advance, Jean

    Viewing 11 reply threads
    • Replies
        • June 9, 2013 at 9:45 pm
        awillett1991
        Participant
          I was on a reduced dose of Zel – 6 pills a day, plus prednisone for rash and many other side effects. Got a year out of it this way.
          • June 9, 2013 at 9:45 pm
          awillett1991
          Participant
            I was on a reduced dose of Zel – 6 pills a day, plus prednisone for rash and many other side effects. Got a year out of it this way.
            • June 9, 2013 at 9:45 pm
            awillett1991
            Participant
              I was on a reduced dose of Zel – 6 pills a day, plus prednisone for rash and many other side effects. Got a year out of it this way.
              • June 10, 2013 at 5:28 pm
              Tim–MRF
              Guest

                Some studies have shown that combining a BRAF inhibitor like Zelboraf with a MEK inhibitor reduces a number of side effects, including rash.  You may want to speak with your doctor about this.  A MEK inhibitor was approved by the FDA a few days ago, under the trade name Mekinist.

                Tim–MRF

                • June 10, 2013 at 5:28 pm
                Tim–MRF
                Guest

                  Some studies have shown that combining a BRAF inhibitor like Zelboraf with a MEK inhibitor reduces a number of side effects, including rash.  You may want to speak with your doctor about this.  A MEK inhibitor was approved by the FDA a few days ago, under the trade name Mekinist.

                  Tim–MRF

                  • June 10, 2013 at 5:28 pm
                  Tim–MRF
                  Guest

                    Some studies have shown that combining a BRAF inhibitor like Zelboraf with a MEK inhibitor reduces a number of side effects, including rash.  You may want to speak with your doctor about this.  A MEK inhibitor was approved by the FDA a few days ago, under the trade name Mekinist.

                    Tim–MRF

                    • June 13, 2013 at 12:13 am
                    joycedixon
                    Participant

                      I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

                      I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

                      immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

                      toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

                      do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

                      scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

                      for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

                       

                      • June 13, 2013 at 12:13 am
                      joycedixon
                      Participant

                        I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

                        I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

                        immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

                        toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

                        do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

                        scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

                        for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

                         

                        • June 13, 2013 at 12:13 am
                        joycedixon
                        Participant

                          I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

                          I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

                          immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

                          toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

                          do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

                          scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

                          for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

                           

                          • June 13, 2013 at 12:15 am
                          joycedixon
                          Participant

                            I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

                            I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

                            immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

                            toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

                            do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

                            scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

                            for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

                            • June 13, 2013 at 12:15 am
                            joycedixon
                            Participant

                              I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

                              I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

                              immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

                              toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

                              do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

                              scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

                              for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

                              • June 13, 2013 at 12:15 am
                              joycedixon
                              Participant

                                I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

                                I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

                                immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

                                toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

                                do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

                                scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

                                for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

                            Viewing 11 reply threads
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