Signatures of mutational processes in human cancer
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Signatures of mutational processes in human cancer

› Forums › General Melanoma Community › Signatures of mutational processes in human cancer

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    • August 14, 2013 at 9:50 pm
    lou2
    Participant

      Holy moley!

      "All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the mutational processes that have been operative. Here we analysed 4,938,362 mutations from 7,042 cancers and extracted more than 20 distinct mutational signatures."

       

      http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12477.html?WT.ec_id=NATURE-20130815

      Holy moley!

      "All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the mutational processes that have been operative. Here we analysed 4,938,362 mutations from 7,042 cancers and extracted more than 20 distinct mutational signatures."

       

      http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12477.html?WT.ec_id=NATURE-20130815

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