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spine

› Forums › General Melanoma Community › spine

  • Post
    • June 4, 2012 at 6:44 pm
    teri0915
    Participant
      Does anyone know much about melanoma in the spine? I see my nero on the 6th but im curious if anyone has any advice to offer. Is it possible to tell if the mass is scar tissue and not living but not growing mel? I had 10 radiation sessions to my spine plus ive had 8 or 9 temodar clycles. I was only supposed to have 12 temodar cycles but im worried about whats going to happen after i finish.
      thanks
      Teri

      Does anyone know much about melanoma in the spine? I see my nero on the 6th but im curious if anyone has any advice to offer. Is it possible to tell if the mass is scar tissue and not living but not growing mel? I had 10 radiation sessions to my spine plus ive had 8 or 9 temodar clycles. I was only supposed to have 12 temodar cycles but im worried about whats going to happen after i finish.
      thanks
      Teri

    Viewing 2 reply threads
    • Replies
        • June 5, 2012 at 1:29 pm
        FormerCaregiver
        Participant

          It is difficult to predict what will happen after you have finished the chemo, as melanoma can be very unpredictable in how it behaves. However, it is likely that other treatments will be needed. Systemic treatments could include TIL treatment (adoptive cell therapy), Yervoy (ipi), IL-2 (interleukin-2), or an anti PD-1 (MDX-1106) clinical trial.

          If one's tumour has the BRAF mutation, Zelboraf can be very effective. However, other drugs such as MEK/PI3K or HSP90 inhibitors (XL888) should ideally be included in the treatment plan. (See: http://clincancerres.aacrjournals.org/content/early/2012/02/18/1078-0432.CCR-11-2612).

          Note that IL-2 before or after Yervoy can make a good combination. Early results of Anti PD-1 trials seem to be very promising from what I have read.

          Hope this helps

          Frank from Australia

            • June 6, 2012 at 1:55 am
            teri0915
            Participant
              Thanks Frank. Its frustrating because it seems like with some other cancers you go through surgery, do chemo/radiation and when its gone its gone but not so much with melanoma.
              unfortunately my tumors are not braf positive. Hopefully we can all be as healthy as possible until someone discovers a better treatment or God willing a cure
              • June 6, 2012 at 1:55 am
              teri0915
              Participant
                Thanks Frank. Its frustrating because it seems like with some other cancers you go through surgery, do chemo/radiation and when its gone its gone but not so much with melanoma.
                unfortunately my tumors are not braf positive. Hopefully we can all be as healthy as possible until someone discovers a better treatment or God willing a cure
                • June 6, 2012 at 1:55 am
                teri0915
                Participant
                  Thanks Frank. Its frustrating because it seems like with some other cancers you go through surgery, do chemo/radiation and when its gone its gone but not so much with melanoma.
                  unfortunately my tumors are not braf positive. Hopefully we can all be as healthy as possible until someone discovers a better treatment or God willing a cure
                • June 5, 2012 at 1:29 pm
                FormerCaregiver
                Participant

                  It is difficult to predict what will happen after you have finished the chemo, as melanoma can be very unpredictable in how it behaves. However, it is likely that other treatments will be needed. Systemic treatments could include TIL treatment (adoptive cell therapy), Yervoy (ipi), IL-2 (interleukin-2), or an anti PD-1 (MDX-1106) clinical trial.

                  If one's tumour has the BRAF mutation, Zelboraf can be very effective. However, other drugs such as MEK/PI3K or HSP90 inhibitors (XL888) should ideally be included in the treatment plan. (See: http://clincancerres.aacrjournals.org/content/early/2012/02/18/1078-0432.CCR-11-2612).

                  Note that IL-2 before or after Yervoy can make a good combination. Early results of Anti PD-1 trials seem to be very promising from what I have read.

                  Hope this helps

                  Frank from Australia

                  • June 5, 2012 at 1:29 pm
                  FormerCaregiver
                  Participant

                    It is difficult to predict what will happen after you have finished the chemo, as melanoma can be very unpredictable in how it behaves. However, it is likely that other treatments will be needed. Systemic treatments could include TIL treatment (adoptive cell therapy), Yervoy (ipi), IL-2 (interleukin-2), or an anti PD-1 (MDX-1106) clinical trial.

                    If one's tumour has the BRAF mutation, Zelboraf can be very effective. However, other drugs such as MEK/PI3K or HSP90 inhibitors (XL888) should ideally be included in the treatment plan. (See: http://clincancerres.aacrjournals.org/content/early/2012/02/18/1078-0432.CCR-11-2612).

                    Note that IL-2 before or after Yervoy can make a good combination. Early results of Anti PD-1 trials seem to be very promising from what I have read.

                    Hope this helps

                    Frank from Australia

                Viewing 2 reply threads
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