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Tafinlar, mekinist, ipi/nivo all together
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Tafinlar, mekinist, ipi/nivo all together

› Forums › General Melanoma Community › Tafinlar, mekinist, ipi/nivo all together

  • Post
    • February 21, 2017 at 11:45 pm
    Hayden30
    Participant

      I've been on taf/Mek for 17 months with amazing results until this last month I had 4 new brain mets. It seems to be working in my body still but not my brain. I also just started ipi/nivo combo and my doctor wants me to continue taking the BRAF meds for at least another month. I'm a little nervous about toxicity with all of this in my system. Does anyone have any experience with these taken together? Or know of any articles or studies combining all 4? Thanks for the help!

       

      sara 

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        • February 22, 2017 at 5:37 pm
        UBContributor
        Participant

          I can't write any experience here, just wanted to witsh you luck with your treatment and ask you to keep us posted,.

          • February 22, 2017 at 7:52 pm
          J.bun
          Participant

            Sara –  First of all – sorry to hear about the mets – and thank goodness modern medicine seems to be providing some options!  … when I was diagnosed as IIIC this Fall and told about the various targeted therapy & immunotherapy options – I did ask about combinations.  My doctor said the toxicity of 4 drugs at the same time has not been tested and is probably too high/dangerous.

            Have you experienced strong side effects from the Taf/Mek?  Do you know if your doctor has managed other people on two treatments/4 drugs concurrently? … these are questions I would ask.  

            (I also think there is an insurance component, not sure if insurance would approve 2 concurrent treatments – but that is opening an entirely different conversation and if you still have the Taf/Mek on-hand, realize this isn't an issue per se).  

            Wishing you the best in the next steps.

            • February 22, 2017 at 11:53 pm
            Bubbles
            Participant
              • February 23, 2017 at 5:52 pm
              Mat
              Participant

                Speaking from experience, not articles or studies.  Ipi with MEK is not good combo for toxicity.  BRAF/MEK with PD-1 is fine.  I'd probably skip the BRAF/MEK for the ipi portion of the treatment and some time thereafter.  I would get the brain mets g-knifed prior to starting ipi/nivo.

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