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temozolmide

› Forums › General Melanoma Community › temozolmide

  • Post
    • September 1, 2014 at 6:58 pm
    starletwoman2007
    Participant
      Can anyone tell me if they have taken temozolmide and whether it has been successful
    Viewing 8 reply threads
    • Replies
        • September 2, 2014 at 11:17 am
        Cooper
        Participant

          I found out it is the same as dacarbazine and response is low, like 10%.  They could show me any studies with it either.  I chose to not take it.

          • September 2, 2014 at 11:17 am
          Cooper
          Participant

            I found out it is the same as dacarbazine and response is low, like 10%.  They could show me any studies with it either.  I chose to not take it.

            • September 2, 2014 at 11:17 am
            Cooper
            Participant

              I found out it is the same as dacarbazine and response is low, like 10%.  They could show me any studies with it either.  I chose to not take it.

                • September 2, 2014 at 4:55 pm
                RJoeyB
                Participant

                  I haven't used temozolomide (a.k.a.).  However, for clarification, temozolomide and dacarbazine are actually different chemotherapies, both in a class of drugs known as "alkylating agents", but chemicallty different.  But yes, both have a low response rate for melanoma.  You'll also see temozolomide used in combination with other agents for biochemotherapy ("biochemo") regimens for melanoma, typically along with interleukin-2 (IL-2), interferon-alpha, and other combinations of "traditional" chemotherapy drugs — I've heard of various combinations that include two or three of temozolomide, cisplatin, carboplatin, dacarbazine, and vinblastine, among others.

                   

                  • September 2, 2014 at 4:56 pm
                  RJoeyB
                  Participant

                    …a.k.a. Temodar…,

                    accidentally deleted that.

                    • September 2, 2014 at 4:56 pm
                    RJoeyB
                    Participant

                      …a.k.a. Temodar…,

                      accidentally deleted that.

                      • September 2, 2014 at 4:56 pm
                      RJoeyB
                      Participant

                        …a.k.a. Temodar…,

                        accidentally deleted that.

                        • September 2, 2014 at 4:55 pm
                        RJoeyB
                        Participant

                          I haven't used temozolomide (a.k.a.).  However, for clarification, temozolomide and dacarbazine are actually different chemotherapies, both in a class of drugs known as "alkylating agents", but chemicallty different.  But yes, both have a low response rate for melanoma.  You'll also see temozolomide used in combination with other agents for biochemotherapy ("biochemo") regimens for melanoma, typically along with interleukin-2 (IL-2), interferon-alpha, and other combinations of "traditional" chemotherapy drugs — I've heard of various combinations that include two or three of temozolomide, cisplatin, carboplatin, dacarbazine, and vinblastine, among others.

                           

                          • September 2, 2014 at 4:55 pm
                          RJoeyB
                          Participant

                            I haven't used temozolomide (a.k.a.).  However, for clarification, temozolomide and dacarbazine are actually different chemotherapies, both in a class of drugs known as "alkylating agents", but chemicallty different.  But yes, both have a low response rate for melanoma.  You'll also see temozolomide used in combination with other agents for biochemotherapy ("biochemo") regimens for melanoma, typically along with interleukin-2 (IL-2), interferon-alpha, and other combinations of "traditional" chemotherapy drugs — I've heard of various combinations that include two or three of temozolomide, cisplatin, carboplatin, dacarbazine, and vinblastine, among others.

                             

                          • September 2, 2014 at 7:53 pm
                          Tim–MRF
                          Guest

                            Temozolomide does not generate large response rates in melanoma, but that is not to say it has no role at all. Sometimes it can knock tumors back temporarily and allow time for other drugs to kick in. I have heard of it being used in patients with brain mets so they would qualify for clinical trials.

                            I also spoke with a Stage IV patient with autoimmune disease and no BRAF mutation. The first disqualified them from immunotherapies and the second from BRAF therapies. Chemo was the only option.

                            And some small group of people have good responses.

                            The decision about taking this chemotherapy should be part of a larger conversation. Certainly better drugs exist now for first-line therapy under normal circumstances.  

                            Hope this helps.

                            Tim–MRF

                             

                              • September 2, 2014 at 8:13 pm
                              RJoeyB
                              Participant

                                Great points Tim.  I also think about the scenario right now where there are people waiting for the approval of pembrolizumab and where temozolomide (or other chemotherapy drugs) might be a good "bridge" option to control or reduce tumor burden for even a couple of months while waiting for the approval and then availability.  As you said, part of a larger conversation and plan.  Especially with all of the changes to melanoma treatment and management these past few years, the role of timing is often underestimated and difficult to manage — I've been playing the timing game for 4 years now and we threw the roadmap away a long time ago.

                                Joe

                                 

                                • September 2, 2014 at 8:38 pm
                                Cooper
                                Participant

                                  However, there isn't any scientific evidence that it works.  There needs to be a trial to see if it does. It is super expensive too!

                                  • September 2, 2014 at 8:38 pm
                                  Cooper
                                  Participant

                                    However, there isn't any scientific evidence that it works.  There needs to be a trial to see if it does. It is super expensive too!

                                    • September 2, 2014 at 8:38 pm
                                    Cooper
                                    Participant

                                      However, there isn't any scientific evidence that it works.  There needs to be a trial to see if it does. It is super expensive too!

                                      • September 2, 2014 at 8:13 pm
                                      RJoeyB
                                      Participant

                                        Great points Tim.  I also think about the scenario right now where there are people waiting for the approval of pembrolizumab and where temozolomide (or other chemotherapy drugs) might be a good "bridge" option to control or reduce tumor burden for even a couple of months while waiting for the approval and then availability.  As you said, part of a larger conversation and plan.  Especially with all of the changes to melanoma treatment and management these past few years, the role of timing is often underestimated and difficult to manage — I've been playing the timing game for 4 years now and we threw the roadmap away a long time ago.

                                        Joe

                                         

                                        • September 2, 2014 at 8:13 pm
                                        RJoeyB
                                        Participant

                                          Great points Tim.  I also think about the scenario right now where there are people waiting for the approval of pembrolizumab and where temozolomide (or other chemotherapy drugs) might be a good "bridge" option to control or reduce tumor burden for even a couple of months while waiting for the approval and then availability.  As you said, part of a larger conversation and plan.  Especially with all of the changes to melanoma treatment and management these past few years, the role of timing is often underestimated and difficult to manage — I've been playing the timing game for 4 years now and we threw the roadmap away a long time ago.

                                          Joe

                                           

                                        • September 2, 2014 at 7:53 pm
                                        Tim–MRF
                                        Guest

                                          Temozolomide does not generate large response rates in melanoma, but that is not to say it has no role at all. Sometimes it can knock tumors back temporarily and allow time for other drugs to kick in. I have heard of it being used in patients with brain mets so they would qualify for clinical trials.

                                          I also spoke with a Stage IV patient with autoimmune disease and no BRAF mutation. The first disqualified them from immunotherapies and the second from BRAF therapies. Chemo was the only option.

                                          And some small group of people have good responses.

                                          The decision about taking this chemotherapy should be part of a larger conversation. Certainly better drugs exist now for first-line therapy under normal circumstances.  

                                          Hope this helps.

                                          Tim–MRF

                                           

                                          • September 2, 2014 at 7:53 pm
                                          Tim–MRF
                                          Guest

                                            Temozolomide does not generate large response rates in melanoma, but that is not to say it has no role at all. Sometimes it can knock tumors back temporarily and allow time for other drugs to kick in. I have heard of it being used in patients with brain mets so they would qualify for clinical trials.

                                            I also spoke with a Stage IV patient with autoimmune disease and no BRAF mutation. The first disqualified them from immunotherapies and the second from BRAF therapies. Chemo was the only option.

                                            And some small group of people have good responses.

                                            The decision about taking this chemotherapy should be part of a larger conversation. Certainly better drugs exist now for first-line therapy under normal circumstances.  

                                            Hope this helps.

                                            Tim–MRF

                                             

                                            • September 4, 2014 at 1:02 pm
                                            hannahcopeland1
                                            Participant

                                              i took 4 rounds of temodar this summer after WBR and during ipi infusions. i have an almost incurable brain disease called lepotmeningeal, but it has almost dissappeared! i dont know if it is because of the combination or one of them individually, but i think it helped. 

                                               

                                              • September 4, 2014 at 1:02 pm
                                              hannahcopeland1
                                              Participant

                                                i took 4 rounds of temodar this summer after WBR and during ipi infusions. i have an almost incurable brain disease called lepotmeningeal, but it has almost dissappeared! i dont know if it is because of the combination or one of them individually, but i think it helped. 

                                                 

                                                • September 4, 2014 at 1:02 pm
                                                hannahcopeland1
                                                Participant

                                                  i took 4 rounds of temodar this summer after WBR and during ipi infusions. i have an almost incurable brain disease called lepotmeningeal, but it has almost dissappeared! i dont know if it is because of the combination or one of them individually, but i think it helped. 

                                                   

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