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Yervoy, non responder, trial next
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Yervoy, non responder, trial next

› Forums › General Melanoma Community › Yervoy, non responder, trial next

  • Post
    • September 1, 2016 at 3:46 pm
    Lee Parlier
    Participant

      I just got the news from my doc at Duke that she she positvive that I am not a resonder to yevoy. She has recommended a trial involving Durvalumab, Tremelimumab, IMCgp100. Does anyone have any knowledge or experience that you could pass on? Any info would be appreciated.

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    • Replies
        • September 1, 2016 at 7:16 pm
        BrianP
        Participant

          Lee,

          Just typed a long response and lost it. 

          Shorter version:  Sorry about your non-response to Ipi.  This same trial is on my short list.  Dr. Salama messaged me a couple days ago and said they are currently enrolling in the Durvalumab + IMCgp100 arm but she thinks they will be enrolling in the Durvalumab + Tremelimumab + IMCgp100 arm later this month.  Either would be a good option IMHO.

          Here is a link on IMCgp100.

          At the bottom of the page there is a link to the ASCO poster on IMCgp100.  In the post Nivo/Pembro era the results aren't spectacular but they are solid.  Just reading about how it works you can see how it might work well in combination with a anti PD-L1 or CTLA-4.

          Good luck Lee.  Hope other have some information to share.

          Brian

           

            • September 1, 2016 at 8:17 pm
            Lee Parlier
            Participant

              I am waiting on my blood work to see if I have a certain gene that will affect the treatment. I start my trial this month if blood work is good without the gene.

              • September 1, 2016 at 8:17 pm
              Lee Parlier
              Participant

                I am waiting on my blood work to see if I have a certain gene that will affect the treatment. I start my trial this month if blood work is good without the gene.

                • September 1, 2016 at 8:17 pm
                Lee Parlier
                Participant

                  I am waiting on my blood work to see if I have a certain gene that will affect the treatment. I start my trial this month if blood work is good without the gene.

                • September 1, 2016 at 7:16 pm
                BrianP
                Participant

                  Lee,

                  Just typed a long response and lost it. 

                  Shorter version:  Sorry about your non-response to Ipi.  This same trial is on my short list.  Dr. Salama messaged me a couple days ago and said they are currently enrolling in the Durvalumab + IMCgp100 arm but she thinks they will be enrolling in the Durvalumab + Tremelimumab + IMCgp100 arm later this month.  Either would be a good option IMHO.

                  Here is a link on IMCgp100.

                  At the bottom of the page there is a link to the ASCO poster on IMCgp100.  In the post Nivo/Pembro era the results aren't spectacular but they are solid.  Just reading about how it works you can see how it might work well in combination with a anti PD-L1 or CTLA-4.

                  Good luck Lee.  Hope other have some information to share.

                  Brian

                   

                  • September 1, 2016 at 7:16 pm
                  BrianP
                  Participant

                    Lee,

                    Just typed a long response and lost it. 

                    Shorter version:  Sorry about your non-response to Ipi.  This same trial is on my short list.  Dr. Salama messaged me a couple days ago and said they are currently enrolling in the Durvalumab + IMCgp100 arm but she thinks they will be enrolling in the Durvalumab + Tremelimumab + IMCgp100 arm later this month.  Either would be a good option IMHO.

                    Here is a link on IMCgp100.

                    At the bottom of the page there is a link to the ASCO poster on IMCgp100.  In the post Nivo/Pembro era the results aren't spectacular but they are solid.  Just reading about how it works you can see how it might work well in combination with a anti PD-L1 or CTLA-4.

                    Good luck Lee.  Hope other have some information to share.

                    Brian

                     

                    • September 1, 2016 at 7:54 pm
                    ed williams
                    Participant

                      Lee, take a look at these two videos, in the second video  at the 16min mark Dr. Omid Hamid talks about gp100. Best Wishes!!!Ed    https://www.youtube.com/watch?v=YfZt5JdJ9_c&index=5&list=PLBeIlaOP6nFBJQlhqQCFM_75iwzT2DRVp  https://www.youtube.com/watch?v=UKwuLmhT3Is

                        • September 1, 2016 at 8:14 pm
                        ed williams
                        Participant

                          Lee, another way to get information is from twitter.  @Dr.OmidHamid  has a twitter account that I follow and if you go to july 11 post on his account and select the link in brackets right after #AACR16  (bit.ly/1wwoyzt) .This will bring you to a presentation he did for other Oncologist a couple of months ago. It is up to date and super informative about all the options we have and where things are going in the Melanoma Immunotherapy field. Best Wishes!!!!Ed

                          • September 1, 2016 at 8:14 pm
                          ed williams
                          Participant

                            Lee, another way to get information is from twitter.  @Dr.OmidHamid  has a twitter account that I follow and if you go to july 11 post on his account and select the link in brackets right after #AACR16  (bit.ly/1wwoyzt) .This will bring you to a presentation he did for other Oncologist a couple of months ago. It is up to date and super informative about all the options we have and where things are going in the Melanoma Immunotherapy field. Best Wishes!!!!Ed

                            • September 1, 2016 at 8:14 pm
                            ed williams
                            Participant

                              Lee, another way to get information is from twitter.  @Dr.OmidHamid  has a twitter account that I follow and if you go to july 11 post on his account and select the link in brackets right after #AACR16  (bit.ly/1wwoyzt) .This will bring you to a presentation he did for other Oncologist a couple of months ago. It is up to date and super informative about all the options we have and where things are going in the Melanoma Immunotherapy field. Best Wishes!!!!Ed

                            • September 1, 2016 at 7:54 pm
                            ed williams
                            Participant

                              Lee, take a look at these two videos, in the second video  at the 16min mark Dr. Omid Hamid talks about gp100. Best Wishes!!!Ed    https://www.youtube.com/watch?v=YfZt5JdJ9_c&index=5&list=PLBeIlaOP6nFBJQlhqQCFM_75iwzT2DRVp  https://www.youtube.com/watch?v=UKwuLmhT3Is

                              • September 1, 2016 at 7:54 pm
                              ed williams
                              Participant

                                Lee, take a look at these two videos, in the second video  at the 16min mark Dr. Omid Hamid talks about gp100. Best Wishes!!!Ed    https://www.youtube.com/watch?v=YfZt5JdJ9_c&index=5&list=PLBeIlaOP6nFBJQlhqQCFM_75iwzT2DRVp  https://www.youtube.com/watch?v=UKwuLmhT3Is

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