Zelboraf side effects

Fortunately the joint pain was tolerable enough for me to be able to run 4 miles 2 months after starting zelboraf. I used the anti-inflamatory diclofinac and glutocosamine/chondroitin. Never had much problem with rashes other than raised sort of like semi-permanent goose bumps. Now I’m about 9 months into the zelboraf. The running lasted about a month and now I’m not able to walk without front pad foot pain….due to a combination of high arches and zelboraf. I think side effects are different for different people. One thing everyone seems to have a problem with is the sun. You will fry quickly without high SPF sunscreen or cover-up.
I hope you’re as fortunate with the side effects as I’ve been.
Bruce.

Fortunately the joint pain was tolerable enough for me to be able to run 4 miles 2 months after starting zelboraf. I used the anti-inflamatory diclofinac and glutocosamine/chondroitin. Never had much problem with rashes other than raised sort of like semi-permanent goose bumps. Now I’m about 9 months into the zelboraf. The running lasted about a month and now I’m not able to walk without front pad foot pain….due to a combination of high arches and zelboraf. I think side effects are different for different people. One thing everyone seems to have a problem with is the sun. You will fry quickly without high SPF sunscreen or cover-up.
I hope you’re as fortunate with the side effects as I’ve been.
Bruce.

Fortunately the joint pain was tolerable enough for me to be able to run 4 miles 2 months after starting zelboraf. I used the anti-inflamatory diclofinac and glutocosamine/chondroitin. Never had much problem with rashes other than raised sort of like semi-permanent goose bumps. Now I’m about 9 months into the zelboraf. The running lasted about a month and now I’m not able to walk without front pad foot pain….due to a combination of high arches and zelboraf. I think side effects are different for different people. One thing everyone seems to have a problem with is the sun. You will fry quickly without high SPF sunscreen or cover-up.
I hope you’re as fortunate with the side effects as I’ve been.
Bruce.

I have been on Zelorf since December. Watch the rash! While it is a common side effect it can turn into Steven Johnson syndrome which can be fatal. I went to bed on the 31st with a minor rash, no itching. by the evening Jan.1 the rash was severe. I had a temp. of 106. ER- given steroids, lab work. Liver functions were very high so remained on steroids for 1 week. Removed from Z for 3 weeks untill Liver Function numbers were in normal range. I am on 1/2 dose now. It is working. Just found out NED. I have had sig. brain mets and lung met. My MDA told me that they " as physicans" are not stressing the sig. of the rash and fever to patients.  Be sure to contact your Dr. so they can monitor the rash. As my rash resolved my skin did peel some. As someone else reminded, be sure to stay covered up. I took my shoes off for less than 10 min. and ended up with a blistering burn that scared. It was crazy, my feet were in the shade at the time as well.  My joints, peridoically hurt. The pain is minor to at times sig. The pain travels around. Feet are always sore though. My hair did thin after 3 weeks but has stopped and am having "regrowth".  Hang in there and hope things go ok for you. Take CareRobyn

I have been on Zelorf since December. Watch the rash! While it is a common side effect it can turn into Steven Johnson syndrome which can be fatal. I went to bed on the 31st with a minor rash, no itching. by the evening Jan.1 the rash was severe. I had a temp. of 106. ER- given steroids, lab work. Liver functions were very high so remained on steroids for 1 week. Removed from Z for 3 weeks untill Liver Function numbers were in normal range. I am on 1/2 dose now. It is working. Just found out NED. I have had sig. brain mets and lung met. My MDA told me that they " as physicans" are not stressing the sig. of the rash and fever to patients.  Be sure to contact your Dr. so they can monitor the rash. As my rash resolved my skin did peel some. As someone else reminded, be sure to stay covered up. I took my shoes off for less than 10 min. and ended up with a blistering burn that scared. It was crazy, my feet were in the shade at the time as well.  My joints, peridoically hurt. The pain is minor to at times sig. The pain travels around. Feet are always sore though. My hair did thin after 3 weeks but has stopped and am having "regrowth".  Hang in there and hope things go ok for you. Take CareRobyn

I have been on Zelorf since December. Watch the rash! While it is a common side effect it can turn into Steven Johnson syndrome which can be fatal. I went to bed on the 31st with a minor rash, no itching. by the evening Jan.1 the rash was severe. I had a temp. of 106. ER- given steroids, lab work. Liver functions were very high so remained on steroids for 1 week. Removed from Z for 3 weeks untill Liver Function numbers were in normal range. I am on 1/2 dose now. It is working. Just found out NED. I have had sig. brain mets and lung met. My MDA told me that they " as physicans" are not stressing the sig. of the rash and fever to patients.  Be sure to contact your Dr. so they can monitor the rash. As my rash resolved my skin did peel some. As someone else reminded, be sure to stay covered up. I took my shoes off for less than 10 min. and ended up with a blistering burn that scared. It was crazy, my feet were in the shade at the time as well.  My joints, peridoically hurt. The pain is minor to at times sig. The pain travels around. Feet are always sore though. My hair did thin after 3 weeks but has stopped and am having "regrowth".  Hang in there and hope things go ok for you. Take CareRobyn

I was on Z for 1 week, when the minor rash turned very severe and spread everywhere. I had to be taken off for 2 weeks and take steroids to get it under control. I did try every topical thing we could find for relief of the rash and the intense itching, but the only thing that seemed to help at all was a cool oatmeal bath. Went back on at 75% dosage and no further problems with that. Still get  small rash and some strange sore lumps under my skin, but they come and go. The overa-ll joint pain was very bad for abt 3 days ( I had to hobble to get anywhere and it was quite pinful) , then it subsided greatly. Now it will be apparent in 1 joint for a day or two, but not to the point where I am needing meds for it. Bottom of feet were also very painful, now tender at times, but very tolerable. Low grade fever comes and goes. Occasional nausea, and once in a while I take phenergan for that. Over – all, I am currently finding the side efffects very tolerable. DO be extremely careful abt the sun!! I burn in under 3 minutes. I stay out of direct sun and when going in and out I have to stay covered with sunscreen, a hat, a parasol and clothing. I am ordering a UV protective shirt to cover my arms when out. VERy VERy photosensitive and I think that even small amts of sun exposure can make the rash worse fairly quickly. I am on day 13 of the reduced dosage. Will be seein my onc in 3 days for labs. 

Hope your rash is behaving itself and that you are doing well. Let us know what your Drs say.

Take Care!!

Tina

I was on Z for 1 week, when the minor rash turned very severe and spread everywhere. I had to be taken off for 2 weeks and take steroids to get it under control. I did try every topical thing we could find for relief of the rash and the intense itching, but the only thing that seemed to help at all was a cool oatmeal bath. Went back on at 75% dosage and no further problems with that. Still get  small rash and some strange sore lumps under my skin, but they come and go. The overa-ll joint pain was very bad for abt 3 days ( I had to hobble to get anywhere and it was quite pinful) , then it subsided greatly. Now it will be apparent in 1 joint for a day or two, but not to the point where I am needing meds for it. Bottom of feet were also very painful, now tender at times, but very tolerable. Low grade fever comes and goes. Occasional nausea, and once in a while I take phenergan for that. Over – all, I am currently finding the side efffects very tolerable. DO be extremely careful abt the sun!! I burn in under 3 minutes. I stay out of direct sun and when going in and out I have to stay covered with sunscreen, a hat, a parasol and clothing. I am ordering a UV protective shirt to cover my arms when out. VERy VERy photosensitive and I think that even small amts of sun exposure can make the rash worse fairly quickly. I am on day 13 of the reduced dosage. Will be seein my onc in 3 days for labs. 

Hope your rash is behaving itself and that you are doing well. Let us know what your Drs say.

Take Care!!

Tina

I was on Z for 1 week, when the minor rash turned very severe and spread everywhere. I had to be taken off for 2 weeks and take steroids to get it under control. I did try every topical thing we could find for relief of the rash and the intense itching, but the only thing that seemed to help at all was a cool oatmeal bath. Went back on at 75% dosage and no further problems with that. Still get  small rash and some strange sore lumps under my skin, but they come and go. The overa-ll joint pain was very bad for abt 3 days ( I had to hobble to get anywhere and it was quite pinful) , then it subsided greatly. Now it will be apparent in 1 joint for a day or two, but not to the point where I am needing meds for it. Bottom of feet were also very painful, now tender at times, but very tolerable. Low grade fever comes and goes. Occasional nausea, and once in a while I take phenergan for that. Over – all, I am currently finding the side efffects very tolerable. DO be extremely careful abt the sun!! I burn in under 3 minutes. I stay out of direct sun and when going in and out I have to stay covered with sunscreen, a hat, a parasol and clothing. I am ordering a UV protective shirt to cover my arms when out. VERy VERy photosensitive and I think that even small amts of sun exposure can make the rash worse fairly quickly. I am on day 13 of the reduced dosage. Will be seein my onc in 3 days for labs. 

Hope your rash is behaving itself and that you are doing well. Let us know what your Drs say.

Take Care!!

Tina

Will finish 9th month on "Z'on Sat. The side effects have been very tolerable.Initally had joint pain for fist month.Lost hair and taste to certain foods.Other side effect was and still is occasional bout of the runs for 1 to 2 days approx. every month.Tumors have shrunk 50-75% as of scans taken in April.This is a life saving drug.Praying it works forever for me and everyone else on it.All the best to you.  Al

Will finish 9th month on "Z'on Sat. The side effects have been very tolerable.Initally had joint pain for fist month.Lost hair and taste to certain foods.Other side effect was and still is occasional bout of the runs for 1 to 2 days approx. every month.Tumors have shrunk 50-75% as of scans taken in April.This is a life saving drug.Praying it works forever for me and everyone else on it.All the best to you.  Al

Will finish 9th month on "Z'on Sat. The side effects have been very tolerable.Initally had joint pain for fist month.Lost hair and taste to certain foods.Other side effect was and still is occasional bout of the runs for 1 to 2 days approx. every month.Tumors have shrunk 50-75% as of scans taken in April.This is a life saving drug.Praying it works forever for me and everyone else on it.All the best to you.  Al

I am on both Zelboraf and a MEK inhibitor through a clinical trial, and both drugs have rash as a side effect. I got it bad after the second week, covering my arms, legs, torso, some on my face. Oatmeal baths were very helpful as someone already mentioned. I also used aloe vera ointment which relived the itching. The rash is now about ten days old and is definitely getting better. I was put on topical steroid ointment on Thursday, but I think it was resolving before then.

Also had joint pains, fever/chills, some nausea. Hit me hardest going into the third week of treatment. Now it is all basically gone except for the rash! It was about five days of hell, now everything is very tolerable!

Eileen L

I am on both Zelboraf and a MEK inhibitor through a clinical trial, and both drugs have rash as a side effect. I got it bad after the second week, covering my arms, legs, torso, some on my face. Oatmeal baths were very helpful as someone already mentioned. I also used aloe vera ointment which relived the itching. The rash is now about ten days old and is definitely getting better. I was put on topical steroid ointment on Thursday, but I think it was resolving before then.

Also had joint pains, fever/chills, some nausea. Hit me hardest going into the third week of treatment. Now it is all basically gone except for the rash! It was about five days of hell, now everything is very tolerable!

Eileen L

I am on both Zelboraf and a MEK inhibitor through a clinical trial, and both drugs have rash as a side effect. I got it bad after the second week, covering my arms, legs, torso, some on my face. Oatmeal baths were very helpful as someone already mentioned. I also used aloe vera ointment which relived the itching. The rash is now about ten days old and is definitely getting better. I was put on topical steroid ointment on Thursday, but I think it was resolving before then.

Also had joint pains, fever/chills, some nausea. Hit me hardest going into the third week of treatment. Now it is all basically gone except for the rash! It was about five days of hell, now everything is very tolerable!

Eileen L

Have been on Z for about a month.  Little joint pain, no significant foot sensitivity.  Oncologist reduced dose to 6 tablets a day as had constant headache.  Continue to have much fatique.  Bubbly rashes on elbows have stopped.  Intermitent bowel issues.  I have canker sores on tongue and gums making eating a challenge.  No kidney or liver problems to date.  Do not know of response by mets yet, but I am hopeful the side effects are worth the hassle.  Also hopeful that itching, fatigue and bowel upset will abate in time.

Prayers and best wishes to our fellow sufferers……………………..Russ

 

Have been on Z for about a month.  Little joint pain, no significant foot sensitivity.  Oncologist reduced dose to 6 tablets a day as had constant headache.  Continue to have much fatique.  Bubbly rashes on elbows have stopped.  Intermitent bowel issues.  I have canker sores on tongue and gums making eating a challenge.  No kidney or liver problems to date.  Do not know of response by mets yet, but I am hopeful the side effects are worth the hassle.  Also hopeful that itching, fatigue and bowel upset will abate in time.

Prayers and best wishes to our fellow sufferers……………………..Russ

 

Have been on Z for about a month.  Little joint pain, no significant foot sensitivity.  Oncologist reduced dose to 6 tablets a day as had constant headache.  Continue to have much fatique.  Bubbly rashes on elbows have stopped.  Intermitent bowel issues.  I have canker sores on tongue and gums making eating a challenge.  No kidney or liver problems to date.  Do not know of response by mets yet, but I am hopeful the side effects are worth the hassle.  Also hopeful that itching, fatigue and bowel upset will abate in time.

Prayers and best wishes to our fellow sufferers……………………..Russ