f2froit

Well, definitely after this second dose, some symptoms (side effects) appeared, swollen muscles (legs and forearms) and joint pains… they are getting a little complicated to deal with, its not that they are terribly painfull, but a constant pain (which doesnt go with our medication) is definitely bad enough.
Im thinking on starting on some topical stuff for sore muscles and joints, like the creams you use after some bad movement or doing some sport… the oncologist didnt give them, but truthfully, he is too much by the book and the alternative would be to give some corticosteroid, which would end up hindering the anti-PD1.

Finally, again to my first question: did anyone, for which this end up working, had new mets under keytruda? I read Celestes blog and definitely Im seeing that anything can happen, but well I like to stay ahead of the curve; Im thinking on some adjuvant treatment.

Bests!!!

Ariel

Well, definitely after this second dose, some symptoms (side effects) appeared, swollen muscles (legs and forearms) and joint pains… they are getting a little complicated to deal with, its not that they are terribly painfull, but a constant pain (which doesnt go with our medication) is definitely bad enough.
Im thinking on starting on some topical stuff for sore muscles and joints, like the creams you use after some bad movement or doing some sport… the oncologist didnt give them, but truthfully, he is too much by the book and the alternative would be to give some corticosteroid, which would end up hindering the anti-PD1.

Finally, again to my first question: did anyone, for which this end up working, had new mets under keytruda? I read Celestes blog and definitely Im seeing that anything can happen, but well I like to stay ahead of the curve; Im thinking on some adjuvant treatment.

Bests!!!

Ariel

Well, definitely after this second dose, some symptoms (side effects) appeared, swollen muscles (legs and forearms) and joint pains… they are getting a little complicated to deal with, its not that they are terribly painfull, but a constant pain (which doesnt go with our medication) is definitely bad enough.
Im thinking on starting on some topical stuff for sore muscles and joints, like the creams you use after some bad movement or doing some sport… the oncologist didnt give them, but truthfully, he is too much by the book and the alternative would be to give some corticosteroid, which would end up hindering the anti-PD1.

Finally, again to my first question: did anyone, for which this end up working, had new mets under keytruda? I read Celestes blog and definitely Im seeing that anything can happen, but well I like to stay ahead of the curve; Im thinking on some adjuvant treatment.

Bests!!!

Ariel

Ok, second dose last Friday, with some surprises, mostly bad ones…

The day prior to administering Keytruda, she had some blood exams performed and on friday the oncologist told us that she had high calcium (11.4). She was having some related symptoms, hence she was:
1) new blood extracted in order to generate a baseline.
2) serum administered in order to hydrate her.
3) Keytruda dose (100mg).
4) hospitalized in order to regulate her calcium properly.

On Saturday she was released from the clinic with 10.5 calcium, but we returned on Monday because of low potasium (side effect of the drug used to lower calcium).

Although last PET (nov 20) only showed subdermal compromise, this calcium might be related to a bone mets, though it can be other strange stuff related to tumors or just that she is being really static (ankle still mending)… it appears to be something related to tumors though 🙁

She is now a little tired, most probably due to this whole event (plus three days in clinic) and lots of needles and having a constant little fever since Saturday of almost 38C.
 

A second thing, that Im noting as interesting at least is that on Friday her LDH level was slightly above normal 370 (prior to Keytruda, first point mentioned above), since then she had several tests performed and it skyrocketed to 1200. I dont know if potasium, calcium or the drug administered to level this can be related, but I dont think so… hence although high LDH might not be good, maybe on this instance it is? Have to keep the wishfull thinking 🙂

Bests to everyone!
Ariel

Ok, second dose last Friday, with some surprises, mostly bad ones…

The day prior to administering Keytruda, she had some blood exams performed and on friday the oncologist told us that she had high calcium (11.4). She was having some related symptoms, hence she was:
1) new blood extracted in order to generate a baseline.
2) serum administered in order to hydrate her.
3) Keytruda dose (100mg).
4) hospitalized in order to regulate her calcium properly.

On Saturday she was released from the clinic with 10.5 calcium, but we returned on Monday because of low potasium (side effect of the drug used to lower calcium).

Although last PET (nov 20) only showed subdermal compromise, this calcium might be related to a bone mets, though it can be other strange stuff related to tumors or just that she is being really static (ankle still mending)… it appears to be something related to tumors though 🙁

She is now a little tired, most probably due to this whole event (plus three days in clinic) and lots of needles and having a constant little fever since Saturday of almost 38C.
 

A second thing, that Im noting as interesting at least is that on Friday her LDH level was slightly above normal 370 (prior to Keytruda, first point mentioned above), since then she had several tests performed and it skyrocketed to 1200. I dont know if potasium, calcium or the drug administered to level this can be related, but I dont think so… hence although high LDH might not be good, maybe on this instance it is? Have to keep the wishfull thinking 🙂

Bests to everyone!
Ariel

Ok, second dose last Friday, with some surprises, mostly bad ones…

The day prior to administering Keytruda, she had some blood exams performed and on friday the oncologist told us that she had high calcium (11.4). She was having some related symptoms, hence she was:
1) new blood extracted in order to generate a baseline.
2) serum administered in order to hydrate her.
3) Keytruda dose (100mg).
4) hospitalized in order to regulate her calcium properly.

On Saturday she was released from the clinic with 10.5 calcium, but we returned on Monday because of low potasium (side effect of the drug used to lower calcium).

Although last PET (nov 20) only showed subdermal compromise, this calcium might be related to a bone mets, though it can be other strange stuff related to tumors or just that she is being really static (ankle still mending)… it appears to be something related to tumors though 🙁

She is now a little tired, most probably due to this whole event (plus three days in clinic) and lots of needles and having a constant little fever since Saturday of almost 38C.
 

A second thing, that Im noting as interesting at least is that on Friday her LDH level was slightly above normal 370 (prior to Keytruda, first point mentioned above), since then she had several tests performed and it skyrocketed to 1200. I dont know if potasium, calcium or the drug administered to level this can be related, but I dont think so… hence although high LDH might not be good, maybe on this instance it is? Have to keep the wishfull thinking 🙂

Bests to everyone!
Ariel