Jane Hearn

My husband has had 5 Keytruda treatments.  He had the temperature spikes like you (actually 3–three nights in a row following his first infusion ) (103.8–I checked with TWO thermometers– but it went right down with Ibuprophen).  His colon quit working after the second infusion. (We ended up in the ER to make sure it wasn't a blockage.  Nope.  Just all fluid hanging out above his colon which wasn't working.  They called it ileus.)  He is currently having A LOT of back pain where he previously had SOME back pain.  It is our opinion (his and mine–not a professional opinion) that the Keytruda response is zeroing in on places where he might have had some inflamation.  He has a hernia, and that area is really bothering him, as well.

He is getting rashes at night, too.  They get red and really itch.  Topical cream is helping. Sometimes, if he breaks the skin while he is scratching, they are visible the next day, but otherwise, they seem to recede during the day. 

I'm sorry you are having such a hard time.  It seems that some people have adverse reactions to Keytruda, but most people do not.  I wish you the best, and hope that your side effects decrease the longer you are on the drug, as they have for my husband.

My husband has had 5 Keytruda treatments.  He had the temperature spikes like you (actually 3–three nights in a row following his first infusion ) (103.8–I checked with TWO thermometers– but it went right down with Ibuprophen).  His colon quit working after the second infusion. (We ended up in the ER to make sure it wasn't a blockage.  Nope.  Just all fluid hanging out above his colon which wasn't working.  They called it ileus.)  He is currently having A LOT of back pain where he previously had SOME back pain.  It is our opinion (his and mine–not a professional opinion) that the Keytruda response is zeroing in on places where he might have had some inflamation.  He has a hernia, and that area is really bothering him, as well.

He is getting rashes at night, too.  They get red and really itch.  Topical cream is helping. Sometimes, if he breaks the skin while he is scratching, they are visible the next day, but otherwise, they seem to recede during the day. 

I'm sorry you are having such a hard time.  It seems that some people have adverse reactions to Keytruda, but most people do not.  I wish you the best, and hope that your side effects decrease the longer you are on the drug, as they have for my husband.

My husband has had 5 Keytruda treatments.  He had the temperature spikes like you (actually 3–three nights in a row following his first infusion ) (103.8–I checked with TWO thermometers– but it went right down with Ibuprophen).  His colon quit working after the second infusion. (We ended up in the ER to make sure it wasn't a blockage.  Nope.  Just all fluid hanging out above his colon which wasn't working.  They called it ileus.)  He is currently having A LOT of back pain where he previously had SOME back pain.  It is our opinion (his and mine–not a professional opinion) that the Keytruda response is zeroing in on places where he might have had some inflamation.  He has a hernia, and that area is really bothering him, as well.

He is getting rashes at night, too.  They get red and really itch.  Topical cream is helping. Sometimes, if he breaks the skin while he is scratching, they are visible the next day, but otherwise, they seem to recede during the day. 

I'm sorry you are having such a hard time.  It seems that some people have adverse reactions to Keytruda, but most people do not.  I wish you the best, and hope that your side effects decrease the longer you are on the drug, as they have for my husband.

My husband is going to the melanoma center at MD Anderson for scans every three months.  He is receiving Keytruda in Kentucky at a nearby hospital Chemotherapy unit.  We feel like he has two oncologists.

My husband is going to the melanoma center at MD Anderson for scans every three months.  He is receiving Keytruda in Kentucky at a nearby hospital Chemotherapy unit.  We feel like he has two oncologists.

My husband is going to the melanoma center at MD Anderson for scans every three months.  He is receiving Keytruda in Kentucky at a nearby hospital Chemotherapy unit.  We feel like he has two oncologists.

I just read "When Breath Becomes Air" yesterday.  It was the first book in a long time that I absolutely couldn't put down; I read it into the night until I was finished.  Not only is it relevant to my life (my husband has stage IV melanoma), but it is a well-written, beautiful, engaging story.  There is good reason this book is currently #1 the NYT Best Sellers List and has been in the top 10 for some time.  

I just read "When Breath Becomes Air" yesterday.  It was the first book in a long time that I absolutely couldn't put down; I read it into the night until I was finished.  Not only is it relevant to my life (my husband has stage IV melanoma), but it is a well-written, beautiful, engaging story.  There is good reason this book is currently #1 the NYT Best Sellers List and has been in the top 10 for some time.  

I just read "When Breath Becomes Air" yesterday.  It was the first book in a long time that I absolutely couldn't put down; I read it into the night until I was finished.  Not only is it relevant to my life (my husband has stage IV melanoma), but it is a well-written, beautiful, engaging story.  There is good reason this book is currently #1 the NYT Best Sellers List and has been in the top 10 for some time.  

After his first Keytruda treatment, my husband had violent chills and profuse sweating (the evening of the infusion).  Chills continued intermittenly, with sweats more frequent.  On the second day following the treatment, his temperature soared.  I wasn't home, so he couldn't find the thermometer, but he took ibuprofen and it went down quickly.  The next evening I was there, and he began chilling,  I took his temperature and it was 98.  The chills continued and I took his temp again a few minutes later.  It was 101+.  He still didn't want to take any medication.  In just a few more minutes it was 103.8.  I couldn't believe it, so I took it again with another thermometer.  103.8 F.  He took 2 ibuprofen, and it began to drop instantly.  30 minutes later he was sweating profusely and his temperature was 97F.  This occured the following evening, as well.  Hasn't happened since.  He has only had two treatments, though. so this was only a couple of weeks ago. 

After his first Keytruda treatment, my husband had violent chills and profuse sweating (the evening of the infusion).  Chills continued intermittenly, with sweats more frequent.  On the second day following the treatment, his temperature soared.  I wasn't home, so he couldn't find the thermometer, but he took ibuprofen and it went down quickly.  The next evening I was there, and he began chilling,  I took his temperature and it was 98.  The chills continued and I took his temp again a few minutes later.  It was 101+.  He still didn't want to take any medication.  In just a few more minutes it was 103.8.  I couldn't believe it, so I took it again with another thermometer.  103.8 F.  He took 2 ibuprofen, and it began to drop instantly.  30 minutes later he was sweating profusely and his temperature was 97F.  This occured the following evening, as well.  Hasn't happened since.  He has only had two treatments, though. so this was only a couple of weeks ago. 

After his first Keytruda treatment, my husband had violent chills and profuse sweating (the evening of the infusion).  Chills continued intermittenly, with sweats more frequent.  On the second day following the treatment, his temperature soared.  I wasn't home, so he couldn't find the thermometer, but he took ibuprofen and it went down quickly.  The next evening I was there, and he began chilling,  I took his temperature and it was 98.  The chills continued and I took his temp again a few minutes later.  It was 101+.  He still didn't want to take any medication.  In just a few more minutes it was 103.8.  I couldn't believe it, so I took it again with another thermometer.  103.8 F.  He took 2 ibuprofen, and it began to drop instantly.  30 minutes later he was sweating profusely and his temperature was 97F.  This occured the following evening, as well.  Hasn't happened since.  He has only had two treatments, though. so this was only a couple of weeks ago.