JerNYC

That is fantastic news and such good timing for the Holidays. Also very encouraging for those of us who have not had success with some of the newer therapies.

Before I proceeded with my current therapy (Ipi) one of the oncologists I saw recommended this or a similar chemo combo. Can you tell me a little more about the side effects and how manageable they were? Thank you.

That is fantastic news and such good timing for the Holidays. Also very encouraging for those of us who have not had success with some of the newer therapies.

Before I proceeded with my current therapy (Ipi) one of the oncologists I saw recommended this or a similar chemo combo. Can you tell me a little more about the side effects and how manageable they were? Thank you.

That is fantastic news and such good timing for the Holidays. Also very encouraging for those of us who have not had success with some of the newer therapies.

Before I proceeded with my current therapy (Ipi) one of the oncologists I saw recommended this or a similar chemo combo. Can you tell me a little more about the side effects and how manageable they were? Thank you.

I have been experiencing very low HGB while on Ipi and am just about to undergo my third blood transfusion in the past 7-8 weeks. The Drs suspect it is internal bleeding, but no one has been able to find the source. I wonder if it is Ipi-related. I also had my HGB collapse while I was on IL-2 earlier this year, but it rectified itself over the following months. This time it is more predictable, falling about 1.5 points every two weeks. I had my last Ipi infusion last week so I'm hoping one way or another things improve.

I have been experiencing very low HGB while on Ipi and am just about to undergo my third blood transfusion in the past 7-8 weeks. The Drs suspect it is internal bleeding, but no one has been able to find the source. I wonder if it is Ipi-related. I also had my HGB collapse while I was on IL-2 earlier this year, but it rectified itself over the following months. This time it is more predictable, falling about 1.5 points every two weeks. I had my last Ipi infusion last week so I'm hoping one way or another things improve.

I have been experiencing very low HGB while on Ipi and am just about to undergo my third blood transfusion in the past 7-8 weeks. The Drs suspect it is internal bleeding, but no one has been able to find the source. I wonder if it is Ipi-related. I also had my HGB collapse while I was on IL-2 earlier this year, but it rectified itself over the following months. This time it is more predictable, falling about 1.5 points every two weeks. I had my last Ipi infusion last week so I'm hoping one way or another things improve.

Hi Kevin

I had a similar experience to Lisa, while I was on anti-PD-1 (the MDX version). I developed a brain met which we addressed with gamma knife. My oncologist indicated it was not uncommon with these monoclonal antibodies to see such "flair". That said, like you I was also taken aback by it all as we don't need these 'diversions' on the road.

I did not respond to anti-PD-1 and went on to Ipi (waiting for scans) and I'm three brain MRIs in from the met and things appear ok. I hope you get good results from the CT and that the brain met situation is addressed asap.

Finally, with respect to anti-PD-1, two oncologists I have spoken to believe that doing the drugs sequentially offers very synergistic benefits. I found Ipi a bit tough (was knocked around by infusions 3 and 4) but I had zero side effects from the anti-PD-1. So I'm a big fan – even though it didn't seem to work for me. I believe there are now numerous trials open for the non-BMS versions of anti-PD-1 and most don't preclude prior Ipi usage.

Best

Jer

Hi Kevin

I had a similar experience to Lisa, while I was on anti-PD-1 (the MDX version). I developed a brain met which we addressed with gamma knife. My oncologist indicated it was not uncommon with these monoclonal antibodies to see such "flair". That said, like you I was also taken aback by it all as we don't need these 'diversions' on the road.

I did not respond to anti-PD-1 and went on to Ipi (waiting for scans) and I'm three brain MRIs in from the met and things appear ok. I hope you get good results from the CT and that the brain met situation is addressed asap.

Finally, with respect to anti-PD-1, two oncologists I have spoken to believe that doing the drugs sequentially offers very synergistic benefits. I found Ipi a bit tough (was knocked around by infusions 3 and 4) but I had zero side effects from the anti-PD-1. So I'm a big fan – even though it didn't seem to work for me. I believe there are now numerous trials open for the non-BMS versions of anti-PD-1 and most don't preclude prior Ipi usage.

Best

Jer

Hi Kevin

I had a similar experience to Lisa, while I was on anti-PD-1 (the MDX version). I developed a brain met which we addressed with gamma knife. My oncologist indicated it was not uncommon with these monoclonal antibodies to see such "flair". That said, like you I was also taken aback by it all as we don't need these 'diversions' on the road.

I did not respond to anti-PD-1 and went on to Ipi (waiting for scans) and I'm three brain MRIs in from the met and things appear ok. I hope you get good results from the CT and that the brain met situation is addressed asap.

Finally, with respect to anti-PD-1, two oncologists I have spoken to believe that doing the drugs sequentially offers very synergistic benefits. I found Ipi a bit tough (was knocked around by infusions 3 and 4) but I had zero side effects from the anti-PD-1. So I'm a big fan – even though it didn't seem to work for me. I believe there are now numerous trials open for the non-BMS versions of anti-PD-1 and most don't preclude prior Ipi usage.

Best

Jer

Thank you. That is so very helpful.

Best holiday wishes to you as well and a long lasting NED for your husband.

J 

Thank you. That is so very helpful.

Best holiday wishes to you as well and a long lasting NED for your husband.

J 

Thank you. That is so very helpful.

Best holiday wishes to you as well and a long lasting NED for your husband.

J 

Angela,

I'm glad you got some answers. I am on the same path as you (Ipi after not responding to MDX-1106). I had been told that these eye symptoms were more common with MDX than with Ipi (I was warned at the outset). I was also told that MDX stays on your receptors for months, so maybe the Ipi on top of the MDX revved up the MDX to cause it? I guess it doesn't really matter as you now have it under control.

Best wishes going forward.

J

Angela,

I'm glad you got some answers. I am on the same path as you (Ipi after not responding to MDX-1106). I had been told that these eye symptoms were more common with MDX than with Ipi (I was warned at the outset). I was also told that MDX stays on your receptors for months, so maybe the Ipi on top of the MDX revved up the MDX to cause it? I guess it doesn't really matter as you now have it under control.

Best wishes going forward.

J

Angela,

I'm glad you got some answers. I am on the same path as you (Ipi after not responding to MDX-1106). I had been told that these eye symptoms were more common with MDX than with Ipi (I was warned at the outset). I was also told that MDX stays on your receptors for months, so maybe the Ipi on top of the MDX revved up the MDX to cause it? I guess it doesn't really matter as you now have it under control.

Best wishes going forward.

J