@melanomabegone
Forum Replies Created
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- February 19, 2012 at 5:07 pm
It pains me to read your history.
I had posted before (http://www.melanoma.org/community/mpip-melanoma-patients-information-page/beating-melanoma-need-post-photos) and other than some expressons of concern for me which I appreciate very much, the other comments had been very negative. I was pointing out, with a lot of credible references that there are many ways to fight cancer. No response from these posts. I will take a chance with this post and If you have an open mind you may wish to check out my link or at the least these new articles below:
http://www.dr-gonzalez.com/melanoma.htm (Dr. Gonzalez's very succesful treatment experiences with long term – as in 16 years – survuval rate including melanoma)
http://scholar.google.com/scholar?q=Antimetastatic+activity+of+curcumin+and+catechin.+Cancer+Lett+1999;141:159–65&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ei=mbE_T_u4Dcy1tweE0-DUBQ&ved=0CBcQgQMwAA (Antimetastatic activity of curcumin)
http://www.touchbriefings.com/pdf/3294/murawaki.pdf (Antitumour Effect of Vitamin K2 on Hepatocellular Carcinoma)
I like to point out to those taking anticoagulants that "drugs like Coumadin® that antagonize vitamin K do more than cause bone loss and arterial calcification. In a model of melanoma in mice, the oral administration of anticoagulant drugs that antagonize vitamin K "drastically promoted metastasis." The promotion of metastasis was almost completely suppressed by the pre-administration of vitamin K3, suggesting that these anticoagulant drugs promote metastasis by specifically antagonizing vitamin K."
This tells you the anticancer benefit of Vitamin K but be assured to use K2 and not K3.
I wish you the very best. Please have an open mind. Let your doctor read these articles.
Dennis (melanomabegone)
-
- February 19, 2012 at 5:07 pm
It pains me to read your history.
I had posted before (http://www.melanoma.org/community/mpip-melanoma-patients-information-page/beating-melanoma-need-post-photos) and other than some expressons of concern for me which I appreciate very much, the other comments had been very negative. I was pointing out, with a lot of credible references that there are many ways to fight cancer. No response from these posts. I will take a chance with this post and If you have an open mind you may wish to check out my link or at the least these new articles below:
http://www.dr-gonzalez.com/melanoma.htm (Dr. Gonzalez's very succesful treatment experiences with long term – as in 16 years – survuval rate including melanoma)
http://scholar.google.com/scholar?q=Antimetastatic+activity+of+curcumin+and+catechin.+Cancer+Lett+1999;141:159–65&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ei=mbE_T_u4Dcy1tweE0-DUBQ&ved=0CBcQgQMwAA (Antimetastatic activity of curcumin)
http://www.touchbriefings.com/pdf/3294/murawaki.pdf (Antitumour Effect of Vitamin K2 on Hepatocellular Carcinoma)
I like to point out to those taking anticoagulants that "drugs like Coumadin® that antagonize vitamin K do more than cause bone loss and arterial calcification. In a model of melanoma in mice, the oral administration of anticoagulant drugs that antagonize vitamin K "drastically promoted metastasis." The promotion of metastasis was almost completely suppressed by the pre-administration of vitamin K3, suggesting that these anticoagulant drugs promote metastasis by specifically antagonizing vitamin K."
This tells you the anticancer benefit of Vitamin K but be assured to use K2 and not K3.
I wish you the very best. Please have an open mind. Let your doctor read these articles.
Dennis (melanomabegone)
-
- February 19, 2012 at 5:07 pm
It pains me to read your history.
I had posted before (http://www.melanoma.org/community/mpip-melanoma-patients-information-page/beating-melanoma-need-post-photos) and other than some expressons of concern for me which I appreciate very much, the other comments had been very negative. I was pointing out, with a lot of credible references that there are many ways to fight cancer. No response from these posts. I will take a chance with this post and If you have an open mind you may wish to check out my link or at the least these new articles below:
http://www.dr-gonzalez.com/melanoma.htm (Dr. Gonzalez's very succesful treatment experiences with long term – as in 16 years – survuval rate including melanoma)
http://scholar.google.com/scholar?q=Antimetastatic+activity+of+curcumin+and+catechin.+Cancer+Lett+1999;141:159–65&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ei=mbE_T_u4Dcy1tweE0-DUBQ&ved=0CBcQgQMwAA (Antimetastatic activity of curcumin)
http://www.touchbriefings.com/pdf/3294/murawaki.pdf (Antitumour Effect of Vitamin K2 on Hepatocellular Carcinoma)
I like to point out to those taking anticoagulants that "drugs like Coumadin® that antagonize vitamin K do more than cause bone loss and arterial calcification. In a model of melanoma in mice, the oral administration of anticoagulant drugs that antagonize vitamin K "drastically promoted metastasis." The promotion of metastasis was almost completely suppressed by the pre-administration of vitamin K3, suggesting that these anticoagulant drugs promote metastasis by specifically antagonizing vitamin K."
This tells you the anticancer benefit of Vitamin K but be assured to use K2 and not K3.
I wish you the very best. Please have an open mind. Let your doctor read these articles.
Dennis (melanomabegone)
-
- February 20, 2012 at 5:07 pm
Let's hope your response will spark some constructive debates.
Thanks
Dennis
-
- February 20, 2012 at 5:07 pm
Let's hope your response will spark some constructive debates.
Thanks
Dennis
-
- February 20, 2012 at 5:07 pm
Let's hope your response will spark some constructive debates.
Thanks
Dennis
-
- February 19, 2012 at 5:20 pm
It is so good to finally see people with an open mind, think outside the box, keep up with what is out there and most importantly being proactive for your own health. I posted before (http://www.melanoma.org/community/mpip-melanoma-patients-information-page/beating-melanoma-need-post-photos) and unfortunately other than a few responses who were concern for me (which I greatly appreciate) the others are not only negative but downright abusive. Since you are obviously openminded, you may wish to visit my post and check out the scientific references I posted.In the mean time I like to include the following including some special excerpts:Selenium – University of Michigan Health SystemThe strongest evidence supporting the anticancer effects of selenium supplementation comes from a double-blind trial of 1,312 Americans with a history of skin cancer who were treated with 200 mcg of yeast-based selenium per day or placebo for 4.5 years, then followed for an additional two years.27 Although no decrease in skin cancers occurred, a dramatic 50% reduction in overall cancer deaths and a 37% reduction in total cancer incidence were observed. A statistically significant 58% decrease in cancers of the colon and rectum was reported.Little is known about the effects of selenium in the treatment of people with existing cancer. Selenium supplementation was reported to improve immune function in colon cancer patients,28 but no long-term follow-up was done to evaluate whether these patients ultimately lived longer or fared better.There is one spice that can prevent as well as treat existing cancer and it is Curcumin. Please read:Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term FoeExcerpt:Most carcinogens activate NF-kB and STAT3 pathways.Numerous agents identified from natural sources can block the NF-nB pathway, including curcumin, resveratrol, ursolic acid, capsaicin, silymarin, guggulsterone, and plumbagin (91 – 97). Several of these agents also suppress the STAT3 pathway (98 – 103), suggesting that they exhibit multiple targets. In addition to agents from natural products, synthetic and semisynthetic agents also inhibit the NF-nB or STAT3 pathway. For example, the semisynthetic compound flavopir- idol has been reported its activity on NF-nB and STAT3 suppression. Pharmacologically, these agents have been shown to be quite safe, and thus, they can be used not for just prevention but also therapy. In human clinical trials, curcumin has been shown to actually down-regulate both the NF-nB and STAT3 pathways (104). To our knowledge, curcumin is the only agent among all those tested in patients that has been shown to down-regulate both the NF-nB and STAT3 pathways (49, 51, 104). By this property, therefore, curcumin has been shown to have potential in the treatment of human pancreatic cancer (51), familial adenomatous polyposis (105), inflamma- tory bowel disease (Crohn’s disease; ref. 106), irritable bowel disease (107), and other proinflammatory diseases (108) in clinical trials.Conclusion Whether the objective is prevention or therapy of cancer, the targets are the same. The evidence described here clearly shows that inflammatory pathways are critical targets in both prevention and therapy of cancer. Therefore, identification of agents/drugs that can suppress these pathways has enormous potential. Most drugs fail because they are monotargeted, toxic, ineffective, and unaffordable by many. Because of cross-talk between the pathways, cancers are caused by dysregulation of multiple pathways. Thus, agents that can suppress NF-nB, STAT3, and other pathways (e.g., PI3K/AKT, HIF-1) are likely to be more effective drugs. Because of their safety and ability to affect multiple targets, natural products are likely to have a special place in the preventive and therapeutic armamentarium for cancer.AAPS J. 2009 Sep;11(3):495-510. Epub 2009 Jul 10.Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
http://www.care2.com/greenliving/a-surprising-cause-of-melanoma.html?page=1
A Surprising Cause of Melanoma Dr. Mercola – January 29, 2012
This basically summarizes and vindicates my previous post that had received such criticism from the close-minded.Antimetastatic activity of curcuminOne vitamin that has attracted a lot of research and attention is Vitamin K, specifically K2. Check out:Drugs like Coumadin® that antagonize vitamin K do more than cause bone loss andarterial calcification. In a model of melanoma in mice, the oral administration ofanticoagulant drugs that antagonize vitamin K "drastically promoted metastasis." Thepromotion of metastasis was almost completely suppressed by the pre-administrationof vitamin K3, suggesting that these anticoagulant drugs promote metastasis byspecifically antagonizing vitamin K.This shows the cancer fighting power of Vitamin K but you do NOT want to take K3 which is toxic. Take K2 if available or MK-7. Check out http://products.mercola.com/vitamin-k/ You can scroll down and read instead of listening to the video.Antitumour Effect of Vitamin K2 on Hepatocellular CarcinomaSince you are open to supplements you would already know about the importance of diet and life style. Allow me to emphasize these points:1. The dosage as recommended by the FDA is the "Minimum Daily Requirement", meaning that if you do not even have these levels you will get sick. However you are not aiming for just survival but for optimum health. Their benefits for cancer prevention or treatment it is dose dependent.2. Other than diet and life style is the importance of digestion. Without proper digestion you cannot get the nutrients and supplements into your body. Take digestive enzymes as needed.3. You do not want too much iron especially if you are in the "older" age group. I will be 71 by March but even younger (as in 50) or women already in menopause do not want too much iron either. Make sure you do not take your Vitamin C with food, especial meat and take it a couple times a day. Also always take your Omega 3 (preferrably Krill Oil if you are not allergic to shellfish) because it contains phospholipids with Vitamin E. Take your Vitamin K2 with Vitamin D3.The only other thing towards optimum health is alkaline water, specifically ionized water. Water ionizer machines is a big topic and I will leave it to yourselves to do your own research.Finally if any of you or someone you know has advance cancer and wish to check out other options (as in traditional plus natural treatments) with a proven tract record of long tern survival (as in 15 years) Check out this link and click through the various cancers he has treated and the survival periods. http://www.dr-gonzalez.com/index.htmDr. Gonzalez's treatment history – melanoma (Great long term survival)Mostly I wish you ALL good health. I hope to hear from you.Dennis (melanomabegone) -
- February 19, 2012 at 5:20 pm
It is so good to finally see people with an open mind, think outside the box, keep up with what is out there and most importantly being proactive for your own health. I posted before (http://www.melanoma.org/community/mpip-melanoma-patients-information-page/beating-melanoma-need-post-photos) and unfortunately other than a few responses who were concern for me (which I greatly appreciate) the others are not only negative but downright abusive. Since you are obviously openminded, you may wish to visit my post and check out the scientific references I posted.In the mean time I like to include the following including some special excerpts:Selenium – University of Michigan Health SystemThe strongest evidence supporting the anticancer effects of selenium supplementation comes from a double-blind trial of 1,312 Americans with a history of skin cancer who were treated with 200 mcg of yeast-based selenium per day or placebo for 4.5 years, then followed for an additional two years.27 Although no decrease in skin cancers occurred, a dramatic 50% reduction in overall cancer deaths and a 37% reduction in total cancer incidence were observed. A statistically significant 58% decrease in cancers of the colon and rectum was reported.Little is known about the effects of selenium in the treatment of people with existing cancer. Selenium supplementation was reported to improve immune function in colon cancer patients,28 but no long-term follow-up was done to evaluate whether these patients ultimately lived longer or fared better.There is one spice that can prevent as well as treat existing cancer and it is Curcumin. Please read:Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term FoeExcerpt:Most carcinogens activate NF-kB and STAT3 pathways.Numerous agents identified from natural sources can block the NF-nB pathway, including curcumin, resveratrol, ursolic acid, capsaicin, silymarin, guggulsterone, and plumbagin (91 – 97). Several of these agents also suppress the STAT3 pathway (98 – 103), suggesting that they exhibit multiple targets. In addition to agents from natural products, synthetic and semisynthetic agents also inhibit the NF-nB or STAT3 pathway. For example, the semisynthetic compound flavopir- idol has been reported its activity on NF-nB and STAT3 suppression. Pharmacologically, these agents have been shown to be quite safe, and thus, they can be used not for just prevention but also therapy. In human clinical trials, curcumin has been shown to actually down-regulate both the NF-nB and STAT3 pathways (104). To our knowledge, curcumin is the only agent among all those tested in patients that has been shown to down-regulate both the NF-nB and STAT3 pathways (49, 51, 104). By this property, therefore, curcumin has been shown to have potential in the treatment of human pancreatic cancer (51), familial adenomatous polyposis (105), inflamma- tory bowel disease (Crohn’s disease; ref. 106), irritable bowel disease (107), and other proinflammatory diseases (108) in clinical trials.Conclusion Whether the objective is prevention or therapy of cancer, the targets are the same. The evidence described here clearly shows that inflammatory pathways are critical targets in both prevention and therapy of cancer. Therefore, identification of agents/drugs that can suppress these pathways has enormous potential. Most drugs fail because they are monotargeted, toxic, ineffective, and unaffordable by many. Because of cross-talk between the pathways, cancers are caused by dysregulation of multiple pathways. Thus, agents that can suppress NF-nB, STAT3, and other pathways (e.g., PI3K/AKT, HIF-1) are likely to be more effective drugs. Because of their safety and ability to affect multiple targets, natural products are likely to have a special place in the preventive and therapeutic armamentarium for cancer.AAPS J. 2009 Sep;11(3):495-510. Epub 2009 Jul 10.Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
http://www.care2.com/greenliving/a-surprising-cause-of-melanoma.html?page=1
A Surprising Cause of Melanoma Dr. Mercola – January 29, 2012
This basically summarizes and vindicates my previous post that had received such criticism from the close-minded.Antimetastatic activity of curcuminOne vitamin that has attracted a lot of research and attention is Vitamin K, specifically K2. Check out:Drugs like Coumadin® that antagonize vitamin K do more than cause bone loss andarterial calcification. In a model of melanoma in mice, the oral administration ofanticoagulant drugs that antagonize vitamin K "drastically promoted metastasis." Thepromotion of metastasis was almost completely suppressed by the pre-administrationof vitamin K3, suggesting that these anticoagulant drugs promote metastasis byspecifically antagonizing vitamin K.This shows the cancer fighting power of Vitamin K but you do NOT want to take K3 which is toxic. Take K2 if available or MK-7. Check out http://products.mercola.com/vitamin-k/ You can scroll down and read instead of listening to the video.Antitumour Effect of Vitamin K2 on Hepatocellular CarcinomaSince you are open to supplements you would already know about the importance of diet and life style. Allow me to emphasize these points:1. The dosage as recommended by the FDA is the "Minimum Daily Requirement", meaning that if you do not even have these levels you will get sick. However you are not aiming for just survival but for optimum health. Their benefits for cancer prevention or treatment it is dose dependent.2. Other than diet and life style is the importance of digestion. Without proper digestion you cannot get the nutrients and supplements into your body. Take digestive enzymes as needed.3. You do not want too much iron especially if you are in the "older" age group. I will be 71 by March but even younger (as in 50) or women already in menopause do not want too much iron either. Make sure you do not take your Vitamin C with food, especial meat and take it a couple times a day. Also always take your Omega 3 (preferrably Krill Oil if you are not allergic to shellfish) because it contains phospholipids with Vitamin E. Take your Vitamin K2 with Vitamin D3.The only other thing towards optimum health is alkaline water, specifically ionized water. Water ionizer machines is a big topic and I will leave it to yourselves to do your own research.Finally if any of you or someone you know has advance cancer and wish to check out other options (as in traditional plus natural treatments) with a proven tract record of long tern survival (as in 15 years) Check out this link and click through the various cancers he has treated and the survival periods. http://www.dr-gonzalez.com/index.htmDr. Gonzalez's treatment history – melanoma (Great long term survival)Mostly I wish you ALL good health. I hope to hear from you.Dennis (melanomabegone) -
- February 19, 2012 at 5:20 pm
It is so good to finally see people with an open mind, think outside the box, keep up with what is out there and most importantly being proactive for your own health. I posted before (http://www.melanoma.org/community/mpip-melanoma-patients-information-page/beating-melanoma-need-post-photos) and unfortunately other than a few responses who were concern for me (which I greatly appreciate) the others are not only negative but downright abusive. Since you are obviously openminded, you may wish to visit my post and check out the scientific references I posted.In the mean time I like to include the following including some special excerpts:Selenium – University of Michigan Health SystemThe strongest evidence supporting the anticancer effects of selenium supplementation comes from a double-blind trial of 1,312 Americans with a history of skin cancer who were treated with 200 mcg of yeast-based selenium per day or placebo for 4.5 years, then followed for an additional two years.27 Although no decrease in skin cancers occurred, a dramatic 50% reduction in overall cancer deaths and a 37% reduction in total cancer incidence were observed. A statistically significant 58% decrease in cancers of the colon and rectum was reported.Little is known about the effects of selenium in the treatment of people with existing cancer. Selenium supplementation was reported to improve immune function in colon cancer patients,28 but no long-term follow-up was done to evaluate whether these patients ultimately lived longer or fared better.There is one spice that can prevent as well as treat existing cancer and it is Curcumin. Please read:Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term FoeExcerpt:Most carcinogens activate NF-kB and STAT3 pathways.Numerous agents identified from natural sources can block the NF-nB pathway, including curcumin, resveratrol, ursolic acid, capsaicin, silymarin, guggulsterone, and plumbagin (91 – 97). Several of these agents also suppress the STAT3 pathway (98 – 103), suggesting that they exhibit multiple targets. In addition to agents from natural products, synthetic and semisynthetic agents also inhibit the NF-nB or STAT3 pathway. For example, the semisynthetic compound flavopir- idol has been reported its activity on NF-nB and STAT3 suppression. Pharmacologically, these agents have been shown to be quite safe, and thus, they can be used not for just prevention but also therapy. In human clinical trials, curcumin has been shown to actually down-regulate both the NF-nB and STAT3 pathways (104). To our knowledge, curcumin is the only agent among all those tested in patients that has been shown to down-regulate both the NF-nB and STAT3 pathways (49, 51, 104). By this property, therefore, curcumin has been shown to have potential in the treatment of human pancreatic cancer (51), familial adenomatous polyposis (105), inflamma- tory bowel disease (Crohn’s disease; ref. 106), irritable bowel disease (107), and other proinflammatory diseases (108) in clinical trials.Conclusion Whether the objective is prevention or therapy of cancer, the targets are the same. The evidence described here clearly shows that inflammatory pathways are critical targets in both prevention and therapy of cancer. Therefore, identification of agents/drugs that can suppress these pathways has enormous potential. Most drugs fail because they are monotargeted, toxic, ineffective, and unaffordable by many. Because of cross-talk between the pathways, cancers are caused by dysregulation of multiple pathways. Thus, agents that can suppress NF-nB, STAT3, and other pathways (e.g., PI3K/AKT, HIF-1) are likely to be more effective drugs. Because of their safety and ability to affect multiple targets, natural products are likely to have a special place in the preventive and therapeutic armamentarium for cancer.AAPS J. 2009 Sep;11(3):495-510. Epub 2009 Jul 10.Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
http://www.care2.com/greenliving/a-surprising-cause-of-melanoma.html?page=1
A Surprising Cause of Melanoma Dr. Mercola – January 29, 2012
This basically summarizes and vindicates my previous post that had received such criticism from the close-minded.Antimetastatic activity of curcuminOne vitamin that has attracted a lot of research and attention is Vitamin K, specifically K2. Check out:Drugs like Coumadin® that antagonize vitamin K do more than cause bone loss andarterial calcification. In a model of melanoma in mice, the oral administration ofanticoagulant drugs that antagonize vitamin K "drastically promoted metastasis." Thepromotion of metastasis was almost completely suppressed by the pre-administrationof vitamin K3, suggesting that these anticoagulant drugs promote metastasis byspecifically antagonizing vitamin K.This shows the cancer fighting power of Vitamin K but you do NOT want to take K3 which is toxic. Take K2 if available or MK-7. Check out http://products.mercola.com/vitamin-k/ You can scroll down and read instead of listening to the video.Antitumour Effect of Vitamin K2 on Hepatocellular CarcinomaSince you are open to supplements you would already know about the importance of diet and life style. Allow me to emphasize these points:1. The dosage as recommended by the FDA is the "Minimum Daily Requirement", meaning that if you do not even have these levels you will get sick. However you are not aiming for just survival but for optimum health. Their benefits for cancer prevention or treatment it is dose dependent.2. Other than diet and life style is the importance of digestion. Without proper digestion you cannot get the nutrients and supplements into your body. Take digestive enzymes as needed.3. You do not want too much iron especially if you are in the "older" age group. I will be 71 by March but even younger (as in 50) or women already in menopause do not want too much iron either. Make sure you do not take your Vitamin C with food, especial meat and take it a couple times a day. Also always take your Omega 3 (preferrably Krill Oil if you are not allergic to shellfish) because it contains phospholipids with Vitamin E. Take your Vitamin K2 with Vitamin D3.The only other thing towards optimum health is alkaline water, specifically ionized water. Water ionizer machines is a big topic and I will leave it to yourselves to do your own research.Finally if any of you or someone you know has advance cancer and wish to check out other options (as in traditional plus natural treatments) with a proven tract record of long tern survival (as in 15 years) Check out this link and click through the various cancers he has treated and the survival periods. http://www.dr-gonzalez.com/index.htmDr. Gonzalez's treatment history – melanoma (Great long term survival)Mostly I wish you ALL good health. I hope to hear from you.Dennis (melanomabegone) -
- December 15, 2011 at 7:46 pm
I hate to blow your mind that cancer CAN be cured sometimes with something very simple.
Reminds me of the fable of two frogs at the bottom of the well looking up at the sky. One frog said to the other: "I know everything out there because I have seen it all" not knowing that the sky she saw and that she thought she knew so well was only a minuscule portion of what is actually out there but that was ALL that she could see.
So brace yourself for yet another bombshell for you because when it comes to curing non-melanoma skin cancer, eggplants comes to the rescue.
http://www.bionational.com/pdf/503-514.pdf
Research Journal of Biological Sciences 2 (4): 503-514, 2007
Solasodine Rhamnosyl Glycosides Specifically Bind Cancer Cell Receptors and Induce Apoptosis and Necrosis. Treatment for Sikn Cancer and Hope for Internal Cancers
http://www.naturalnews.com/027506_eggplant_skin_cancer.html
Eggplant Cures Skin Cancer
Tuesday, November 17, 2009 by: Melanie Grimes
BEC5 works by bonding to a receptor on the surface of the cancer cell. After the cell digests the eggplant extract, it causes the cell to rupture. The cancer cell is destroyed and its contents are then reabsorbed by the body.
BEC5 has been proven effective in treating over 80,000 cases of skin cancer, preventing surgery. The types of cancer treated by eggplant are both invasive and non-invasive non-melanoma skin cancers. In every case the cancers went into remission and did not return. Australians have been curing their skin cancers using these phytochemicals for decades.
BEC5 acts by killing cancer cells without harming any other healthy cells in the human body. BEC5 can also be used to treat actinic keratose, the precursor to cancer, as well as age or sunspots on the skin.
Actinic keratoses are a possible predictor of skin cancer. These red patches caused by sun exposure are made of abnormal cells that can mutate into malignant cells in the basal, or lower layers of the skin. Squamous cell carcinomas are another common form of skin cancer, and one which causes nearly two thousands deaths annually. This wart-type growth has irregular borders and can also be treated with the eggplant extract.
Used as a cream for over twenty-five years in clinical trials in both Australia and the United Kingdom, BEC5 had success rate of over 78% when applied for eight weeks. Used for 12 weeks, the cream had a 100% success rate in removing cancers, none of which returned for the following five years.
Over one million new cases of non-melanoma skin cancers are diagnosed each year in the United States alone. Skin cancer is now the most common illness in men over the age of 50. It is even more common than lung, prostate or colon cancer. Incidences are so common that one out of three Caucasians are now expected to develop skin cancer at some point in their lives. With this simple, natural remedy, many surgeries might be prevented and health restored.
http://ahha.org/SkinCancerCure.htm
http://www.lmreview.com/articles/eg…
http://www.cancer.org/docroot/lrn/l…
Learn more:
http://www.naturalnews.com/027506_eggplant_skin_cancer.html#ixzz1gcaOSl4A
http://www.bionational.com/library_pages/article-016-Curaderm_History.html
The History of Curaderm
Curaderm-BEC5 is intended to specifically treat:
- Basal Cell Carcinomas (BCC)
- Squamous Cell Carcinomas (SCC)
- Keratoses
- Keratoacanthomas
- Sun spots
References:
Punjabi, S., I. Cook, P. Kersey, R. Marks, A. Finlay, G. Sharpe, et al. 2000. A double blind, multi-centre parallel group study of BEC-5 cream in basal cell carcinoma. Eur. Acad. Dermatol. Venereol. 14:47-60.
Cerio, R. and S. Punjabi, 2002. Clinical appraisal of BEC5. Barts and the London NHS.
Cham, B. E., B. Daunter and R. Evans, 1992. Topical treatment of malignant and premalignant skin cancers by very low concentrations of a standard mixture of salasodine glycosides. Clin. Digest Series Dermatol., 1992.
Cham, B.E., 1994. Saloasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies. Asia Pacif. J. Pharmacol., 9:113-118.
AND FROM THE JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY:
http://pubs.acs.org/doi/abs/10.1021/jf062204q
Antiangiogenic Activity of Brown Algae Fucoxanthin and Its Deacetylated Product, Fucoxanthinol
J. Agric. Food Chem., 2006, 54 (26), pp 9805–9810
DOI: 10.1021/jf062204q
Publication Date (Web): December 20, 2006
Abstract
The antiangiogenic effects of fucoxanthin and a deacetylated product, fucoxanthinol, were examined. Fucoxanthin significantly suppressed HUVEC proliferation and tube formation at more than 10 μM, but it had no significant effect on HUVEC chemotaxis. The formation of blood vessel-like structures from CD31-positive cells was evaluated using embryonic stem cell-derived embryoid bodies. Fucoxanthin effectively suppressed the development of these structures at 10−20 μM, suggesting that it could suppress differentiation of endothelial progenitor cells into endothelial cells involving new blood vessel formation. Fucoxanthin and fucoxanthinol suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring, in a dose-dependent manner. These results imply that fucoxanthin having antiangiogenic activity might be useful in preventing angiogenesis-related diseases.
http://pubs.acs.org/doi/abs/10.1021/jf801322m
Structures and Antioxidant Activity of Anthocyanins in Many Accessions of Eggplant and Its Related Species
J. Agric. Food Chem., 2008, 56 (21), pp 10154–10159
DOI: 10.1021/jf801322m
Publication Date (Web): October 3, 2008
Abstract
Anthocyanins were detected in extracts from the peels of 123 accessions of eggplant (Solanum melongena) and its related species. Their anthocyanin profiles were classified into four types, including known Japanese eggplant type (type 1) and non-Japanese eggplant type (type 2). Although most of the eggplant accessions had one of the two known profiles, one accession had a novel profile (type 3). Two accessions of related species showed another novel profile (type 4). The major anthocyanins were identified as delphinidin 3-(p-coumaroylrutinoside)-5-glucoside (nasunin) (type 1), delphinidin 3-rutinoside (type 2), delphinidin 3-glucoside (type 3), and petunidin 3-(p-coumaroylrutinoside)-5-glucoside (petunidin 3RGc5G) (type 4). Delphinidin 3-caffeoylrutinoside-5-glucoside (delphinidin 3RGcaf5G) was isolated from the hybrid (F1) plants of a type 1 cultivar and a type 3 germplasm. Among the five purified anthocyanins, delphinidin 3RGcaf5G showed the highest radical-scavenging activities toward both 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and linoleic acid radical, followed in order by nasunin and petunidin 3RGc5G.
http://pubs.acs.org/doi/abs/10.1021/jf050796r
Antiangiogenic Activity of Nasunin, an Antioxidant Anthocyanin, in Eggplant Peels
J. Agric. Food Chem., 2005, 53 (16), pp 6272–6275
DOI: 10.1021/jf050796r
Publication Date (Web): July 7, 2005
Abstract
Nasunin, delphinidin-3-(p-coumaroylrutinoside)-5-glucoside, an antioxidant anthocyanin isolated from eggplant peels, was demonstrated as an angiogenesis inhibitor. Nasunin at higher 10 μM suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring. The effect of nasunin was examined in various in vitro angiogenesis models using human umbilical vein endothelial cells (HUVECs). Nasunin suppressed HUVEC proliferation in a dose-dependent manner (50−200 μM); however, it had no significant effect on HUVEC chemotaxis in a Boyden chamber assay and HUVEC tube formation on a reconstituted basement membrane. These results imply that nasunin with both antioxidant and antiangiogenic activities might be useful to prevent angiogenesis-related diseases.
http://pubs.acs.org/doi/abs/10.1021/jf801322m
Structures and Antioxidant Activity of Anthocyanins in Many Accessions of Eggplant and Its Related Species
J. Agric. Food Chem., 2008, 56 (21), pp 10154–10159
DOI: 10.1021/jf801322m
Publication Date (Web): October 3, 2008
Abstract
Anthocyanins were detected in extracts from the peels of 123 accessions of eggplant (Solanum melongena) and its related species. Their anthocyanin profiles were classified into four types, including known Japanese eggplant type (type 1) and non-Japanese eggplant type (type 2). Although most of the eggplant accessions had one of the two known profiles, one accession had a novel profile (type 3). Two accessions of related species showed another novel profile (type 4). The major anthocyanins were identified as delphinidin 3-(p-coumaroylrutinoside)-5-glucoside (nasunin) (type 1), delphinidin 3-rutinoside (type 2), delphinidin 3-glucoside (type 3), and petunidin 3-(p-coumaroylrutinoside)-5-glucoside (petunidin 3RGc5G) (type 4). Delphinidin 3-caffeoylrutinoside-5-glucoside (delphinidin 3RGcaf5G) was isolated from the hybrid (F1) plants of a type 1 cultivar and a type 3 germplasm. Among the five purified anthocyanins, delphinidin 3RGcaf5G showed the highest radical-scavenging activities toward both 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and linoleic acid radical, followed in order by nasunin and petunidin 3RGc5G.
http://pubs.acs.org/doi/abs/10.1021/jf051841y
Nasunin from Eggplant Consists of Cis−Trans Isomers of Delphinidin 3-[4-(p-Coumaroyl)-l-rhamnosyl (1→6)glucopyranoside]-5-glucopyranoside
J. Agric. Food Chem., 2005, 53 (24), pp 9472–9477
DOI: 10.1021/jf051841y
Publication Date (Web): November 1, 2005
Abstract
Two major anthocyanins were isolated from the acidified methanolic extract of eggplant (Solanum melongena L.) by column chromatography and preparative high-performance liquid chromatography. These anthocyanins were interconvertible under room light illumination condition. By means of tandem time-of-flight mass spectrometry and nuclear magnetic resonance spectroscopy, their structures were identified and elucidated as delphinidin 3-[4-(cis-p-coumaroyl)-l-rhamnosyl(1→6)glucopyranoside]-5-glucopyranoside (compound 1) and delphinidin 3-[4-(trans-p-coumaroyl)-l-rhamnosyl-(1→6)glucopyranoside]-5-glucopyranoside (compound 2), respectively. The results indicated that nasunin comprised cis and trans isomers of the p-coumaric acid moiety in its structure.
I hope the above information is not too "confusing" for you as per your post. While it is uplifting to see the support for each other for what you are all going through or have gone through in this blog, it is also depressing to see that it appears that all the participants just sit there letting their oncologist do whatever without realising that beating cancer is a team effort between the oncologist and the patient. There are a lot you can do to not only effect a better outcome and suffer less side effects but also to maxomize the chance that the cancer does not returm. Here we are talking about your life style, your diet, supplements of vitamins, antioxidants as well as spices especially curcumin as I had posted earlier. More so is that when you are proactive doing your part and empowering yourself to be responsible for your health and to fight the cancer you don't feel as helpless and depressed as opposed to just sitting there "taking it" which will make for a less optimum outcome. Your emotional and psychological well being DOES affect the progress and outcome of yout treatment. Don't take my word for it. Ask your doctor!
Good luck to you all and good bye.
Dennis (melanomabegone)
-
- December 15, 2011 at 7:46 pm
I hate to blow your mind that cancer CAN be cured sometimes with something very simple.
Reminds me of the fable of two frogs at the bottom of the well looking up at the sky. One frog said to the other: "I know everything out there because I have seen it all" not knowing that the sky she saw and that she thought she knew so well was only a minuscule portion of what is actually out there but that was ALL that she could see.
So brace yourself for yet another bombshell for you because when it comes to curing non-melanoma skin cancer, eggplants comes to the rescue.
http://www.bionational.com/pdf/503-514.pdf
Research Journal of Biological Sciences 2 (4): 503-514, 2007
Solasodine Rhamnosyl Glycosides Specifically Bind Cancer Cell Receptors and Induce Apoptosis and Necrosis. Treatment for Sikn Cancer and Hope for Internal Cancers
http://www.naturalnews.com/027506_eggplant_skin_cancer.html
Eggplant Cures Skin Cancer
Tuesday, November 17, 2009 by: Melanie Grimes
BEC5 works by bonding to a receptor on the surface of the cancer cell. After the cell digests the eggplant extract, it causes the cell to rupture. The cancer cell is destroyed and its contents are then reabsorbed by the body.
BEC5 has been proven effective in treating over 80,000 cases of skin cancer, preventing surgery. The types of cancer treated by eggplant are both invasive and non-invasive non-melanoma skin cancers. In every case the cancers went into remission and did not return. Australians have been curing their skin cancers using these phytochemicals for decades.
BEC5 acts by killing cancer cells without harming any other healthy cells in the human body. BEC5 can also be used to treat actinic keratose, the precursor to cancer, as well as age or sunspots on the skin.
Actinic keratoses are a possible predictor of skin cancer. These red patches caused by sun exposure are made of abnormal cells that can mutate into malignant cells in the basal, or lower layers of the skin. Squamous cell carcinomas are another common form of skin cancer, and one which causes nearly two thousands deaths annually. This wart-type growth has irregular borders and can also be treated with the eggplant extract.
Used as a cream for over twenty-five years in clinical trials in both Australia and the United Kingdom, BEC5 had success rate of over 78% when applied for eight weeks. Used for 12 weeks, the cream had a 100% success rate in removing cancers, none of which returned for the following five years.
Over one million new cases of non-melanoma skin cancers are diagnosed each year in the United States alone. Skin cancer is now the most common illness in men over the age of 50. It is even more common than lung, prostate or colon cancer. Incidences are so common that one out of three Caucasians are now expected to develop skin cancer at some point in their lives. With this simple, natural remedy, many surgeries might be prevented and health restored.
http://ahha.org/SkinCancerCure.htm
http://www.lmreview.com/articles/eg…
http://www.cancer.org/docroot/lrn/l…
Learn more:
http://www.naturalnews.com/027506_eggplant_skin_cancer.html#ixzz1gcaOSl4A
http://www.bionational.com/library_pages/article-016-Curaderm_History.html
The History of Curaderm
Curaderm-BEC5 is intended to specifically treat:
- Basal Cell Carcinomas (BCC)
- Squamous Cell Carcinomas (SCC)
- Keratoses
- Keratoacanthomas
- Sun spots
References:
Punjabi, S., I. Cook, P. Kersey, R. Marks, A. Finlay, G. Sharpe, et al. 2000. A double blind, multi-centre parallel group study of BEC-5 cream in basal cell carcinoma. Eur. Acad. Dermatol. Venereol. 14:47-60.
Cerio, R. and S. Punjabi, 2002. Clinical appraisal of BEC5. Barts and the London NHS.
Cham, B. E., B. Daunter and R. Evans, 1992. Topical treatment of malignant and premalignant skin cancers by very low concentrations of a standard mixture of salasodine glycosides. Clin. Digest Series Dermatol., 1992.
Cham, B.E., 1994. Saloasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies. Asia Pacif. J. Pharmacol., 9:113-118.
AND FROM THE JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY:
http://pubs.acs.org/doi/abs/10.1021/jf062204q
Antiangiogenic Activity of Brown Algae Fucoxanthin and Its Deacetylated Product, Fucoxanthinol
J. Agric. Food Chem., 2006, 54 (26), pp 9805–9810
DOI: 10.1021/jf062204q
Publication Date (Web): December 20, 2006
Abstract
The antiangiogenic effects of fucoxanthin and a deacetylated product, fucoxanthinol, were examined. Fucoxanthin significantly suppressed HUVEC proliferation and tube formation at more than 10 μM, but it had no significant effect on HUVEC chemotaxis. The formation of blood vessel-like structures from CD31-positive cells was evaluated using embryonic stem cell-derived embryoid bodies. Fucoxanthin effectively suppressed the development of these structures at 10−20 μM, suggesting that it could suppress differentiation of endothelial progenitor cells into endothelial cells involving new blood vessel formation. Fucoxanthin and fucoxanthinol suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring, in a dose-dependent manner. These results imply that fucoxanthin having antiangiogenic activity might be useful in preventing angiogenesis-related diseases.
http://pubs.acs.org/doi/abs/10.1021/jf801322m
Structures and Antioxidant Activity of Anthocyanins in Many Accessions of Eggplant and Its Related Species
J. Agric. Food Chem., 2008, 56 (21), pp 10154–10159
DOI: 10.1021/jf801322m
Publication Date (Web): October 3, 2008
Abstract
Anthocyanins were detected in extracts from the peels of 123 accessions of eggplant (Solanum melongena) and its related species. Their anthocyanin profiles were classified into four types, including known Japanese eggplant type (type 1) and non-Japanese eggplant type (type 2). Although most of the eggplant accessions had one of the two known profiles, one accession had a novel profile (type 3). Two accessions of related species showed another novel profile (type 4). The major anthocyanins were identified as delphinidin 3-(p-coumaroylrutinoside)-5-glucoside (nasunin) (type 1), delphinidin 3-rutinoside (type 2), delphinidin 3-glucoside (type 3), and petunidin 3-(p-coumaroylrutinoside)-5-glucoside (petunidin 3RGc5G) (type 4). Delphinidin 3-caffeoylrutinoside-5-glucoside (delphinidin 3RGcaf5G) was isolated from the hybrid (F1) plants of a type 1 cultivar and a type 3 germplasm. Among the five purified anthocyanins, delphinidin 3RGcaf5G showed the highest radical-scavenging activities toward both 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and linoleic acid radical, followed in order by nasunin and petunidin 3RGc5G.
http://pubs.acs.org/doi/abs/10.1021/jf050796r
Antiangiogenic Activity of Nasunin, an Antioxidant Anthocyanin, in Eggplant Peels
J. Agric. Food Chem., 2005, 53 (16), pp 6272–6275
DOI: 10.1021/jf050796r
Publication Date (Web): July 7, 2005
Abstract
Nasunin, delphinidin-3-(p-coumaroylrutinoside)-5-glucoside, an antioxidant anthocyanin isolated from eggplant peels, was demonstrated as an angiogenesis inhibitor. Nasunin at higher 10 μM suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring. The effect of nasunin was examined in various in vitro angiogenesis models using human umbilical vein endothelial cells (HUVECs). Nasunin suppressed HUVEC proliferation in a dose-dependent manner (50−200 μM); however, it had no significant effect on HUVEC chemotaxis in a Boyden chamber assay and HUVEC tube formation on a reconstituted basement membrane. These results imply that nasunin with both antioxidant and antiangiogenic activities might be useful to prevent angiogenesis-related diseases.
http://pubs.acs.org/doi/abs/10.1021/jf801322m
Structures and Antioxidant Activity of Anthocyanins in Many Accessions of Eggplant and Its Related Species
J. Agric. Food Chem., 2008, 56 (21), pp 10154–10159
DOI: 10.1021/jf801322m
Publication Date (Web): October 3, 2008
Abstract
Anthocyanins were detected in extracts from the peels of 123 accessions of eggplant (Solanum melongena) and its related species. Their anthocyanin profiles were classified into four types, including known Japanese eggplant type (type 1) and non-Japanese eggplant type (type 2). Although most of the eggplant accessions had one of the two known profiles, one accession had a novel profile (type 3). Two accessions of related species showed another novel profile (type 4). The major anthocyanins were identified as delphinidin 3-(p-coumaroylrutinoside)-5-glucoside (nasunin) (type 1), delphinidin 3-rutinoside (type 2), delphinidin 3-glucoside (type 3), and petunidin 3-(p-coumaroylrutinoside)-5-glucoside (petunidin 3RGc5G) (type 4). Delphinidin 3-caffeoylrutinoside-5-glucoside (delphinidin 3RGcaf5G) was isolated from the hybrid (F1) plants of a type 1 cultivar and a type 3 germplasm. Among the five purified anthocyanins, delphinidin 3RGcaf5G showed the highest radical-scavenging activities toward both 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and linoleic acid radical, followed in order by nasunin and petunidin 3RGc5G.
http://pubs.acs.org/doi/abs/10.1021/jf051841y
Nasunin from Eggplant Consists of Cis−Trans Isomers of Delphinidin 3-[4-(p-Coumaroyl)-l-rhamnosyl (1→6)glucopyranoside]-5-glucopyranoside
J. Agric. Food Chem., 2005, 53 (24), pp 9472–9477
DOI: 10.1021/jf051841y
Publication Date (Web): November 1, 2005
Abstract
Two major anthocyanins were isolated from the acidified methanolic extract of eggplant (Solanum melongena L.) by column chromatography and preparative high-performance liquid chromatography. These anthocyanins were interconvertible under room light illumination condition. By means of tandem time-of-flight mass spectrometry and nuclear magnetic resonance spectroscopy, their structures were identified and elucidated as delphinidin 3-[4-(cis-p-coumaroyl)-l-rhamnosyl(1→6)glucopyranoside]-5-glucopyranoside (compound 1) and delphinidin 3-[4-(trans-p-coumaroyl)-l-rhamnosyl-(1→6)glucopyranoside]-5-glucopyranoside (compound 2), respectively. The results indicated that nasunin comprised cis and trans isomers of the p-coumaric acid moiety in its structure.
I hope the above information is not too "confusing" for you as per your post. While it is uplifting to see the support for each other for what you are all going through or have gone through in this blog, it is also depressing to see that it appears that all the participants just sit there letting their oncologist do whatever without realising that beating cancer is a team effort between the oncologist and the patient. There are a lot you can do to not only effect a better outcome and suffer less side effects but also to maxomize the chance that the cancer does not returm. Here we are talking about your life style, your diet, supplements of vitamins, antioxidants as well as spices especially curcumin as I had posted earlier. More so is that when you are proactive doing your part and empowering yourself to be responsible for your health and to fight the cancer you don't feel as helpless and depressed as opposed to just sitting there "taking it" which will make for a less optimum outcome. Your emotional and psychological well being DOES affect the progress and outcome of yout treatment. Don't take my word for it. Ask your doctor!
Good luck to you all and good bye.
Dennis (melanomabegone)
-
- December 15, 2011 at 7:46 pm
I hate to blow your mind that cancer CAN be cured sometimes with something very simple.
Reminds me of the fable of two frogs at the bottom of the well looking up at the sky. One frog said to the other: "I know everything out there because I have seen it all" not knowing that the sky she saw and that she thought she knew so well was only a minuscule portion of what is actually out there but that was ALL that she could see.
So brace yourself for yet another bombshell for you because when it comes to curing non-melanoma skin cancer, eggplants comes to the rescue.
http://www.bionational.com/pdf/503-514.pdf
Research Journal of Biological Sciences 2 (4): 503-514, 2007
Solasodine Rhamnosyl Glycosides Specifically Bind Cancer Cell Receptors and Induce Apoptosis and Necrosis. Treatment for Sikn Cancer and Hope for Internal Cancers
http://www.naturalnews.com/027506_eggplant_skin_cancer.html
Eggplant Cures Skin Cancer
Tuesday, November 17, 2009 by: Melanie Grimes
BEC5 works by bonding to a receptor on the surface of the cancer cell. After the cell digests the eggplant extract, it causes the cell to rupture. The cancer cell is destroyed and its contents are then reabsorbed by the body.
BEC5 has been proven effective in treating over 80,000 cases of skin cancer, preventing surgery. The types of cancer treated by eggplant are both invasive and non-invasive non-melanoma skin cancers. In every case the cancers went into remission and did not return. Australians have been curing their skin cancers using these phytochemicals for decades.
BEC5 acts by killing cancer cells without harming any other healthy cells in the human body. BEC5 can also be used to treat actinic keratose, the precursor to cancer, as well as age or sunspots on the skin.
Actinic keratoses are a possible predictor of skin cancer. These red patches caused by sun exposure are made of abnormal cells that can mutate into malignant cells in the basal, or lower layers of the skin. Squamous cell carcinomas are another common form of skin cancer, and one which causes nearly two thousands deaths annually. This wart-type growth has irregular borders and can also be treated with the eggplant extract.
Used as a cream for over twenty-five years in clinical trials in both Australia and the United Kingdom, BEC5 had success rate of over 78% when applied for eight weeks. Used for 12 weeks, the cream had a 100% success rate in removing cancers, none of which returned for the following five years.
Over one million new cases of non-melanoma skin cancers are diagnosed each year in the United States alone. Skin cancer is now the most common illness in men over the age of 50. It is even more common than lung, prostate or colon cancer. Incidences are so common that one out of three Caucasians are now expected to develop skin cancer at some point in their lives. With this simple, natural remedy, many surgeries might be prevented and health restored.
http://ahha.org/SkinCancerCure.htm
http://www.lmreview.com/articles/eg…
http://www.cancer.org/docroot/lrn/l…
Learn more:
http://www.naturalnews.com/027506_eggplant_skin_cancer.html#ixzz1gcaOSl4A
http://www.bionational.com/library_pages/article-016-Curaderm_History.html
The History of Curaderm
Curaderm-BEC5 is intended to specifically treat:
- Basal Cell Carcinomas (BCC)
- Squamous Cell Carcinomas (SCC)
- Keratoses
- Keratoacanthomas
- Sun spots
References:
Punjabi, S., I. Cook, P. Kersey, R. Marks, A. Finlay, G. Sharpe, et al. 2000. A double blind, multi-centre parallel group study of BEC-5 cream in basal cell carcinoma. Eur. Acad. Dermatol. Venereol. 14:47-60.
Cerio, R. and S. Punjabi, 2002. Clinical appraisal of BEC5. Barts and the London NHS.
Cham, B. E., B. Daunter and R. Evans, 1992. Topical treatment of malignant and premalignant skin cancers by very low concentrations of a standard mixture of salasodine glycosides. Clin. Digest Series Dermatol., 1992.
Cham, B.E., 1994. Saloasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies. Asia Pacif. J. Pharmacol., 9:113-118.
AND FROM THE JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY:
http://pubs.acs.org/doi/abs/10.1021/jf062204q
Antiangiogenic Activity of Brown Algae Fucoxanthin and Its Deacetylated Product, Fucoxanthinol
J. Agric. Food Chem., 2006, 54 (26), pp 9805–9810
DOI: 10.1021/jf062204q
Publication Date (Web): December 20, 2006
Abstract
The antiangiogenic effects of fucoxanthin and a deacetylated product, fucoxanthinol, were examined. Fucoxanthin significantly suppressed HUVEC proliferation and tube formation at more than 10 μM, but it had no significant effect on HUVEC chemotaxis. The formation of blood vessel-like structures from CD31-positive cells was evaluated using embryonic stem cell-derived embryoid bodies. Fucoxanthin effectively suppressed the development of these structures at 10−20 μM, suggesting that it could suppress differentiation of endothelial progenitor cells into endothelial cells involving new blood vessel formation. Fucoxanthin and fucoxanthinol suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring, in a dose-dependent manner. These results imply that fucoxanthin having antiangiogenic activity might be useful in preventing angiogenesis-related diseases.
http://pubs.acs.org/doi/abs/10.1021/jf801322m
Structures and Antioxidant Activity of Anthocyanins in Many Accessions of Eggplant and Its Related Species
J. Agric. Food Chem., 2008, 56 (21), pp 10154–10159
DOI: 10.1021/jf801322m
Publication Date (Web): October 3, 2008
Abstract
Anthocyanins were detected in extracts from the peels of 123 accessions of eggplant (Solanum melongena) and its related species. Their anthocyanin profiles were classified into four types, including known Japanese eggplant type (type 1) and non-Japanese eggplant type (type 2). Although most of the eggplant accessions had one of the two known profiles, one accession had a novel profile (type 3). Two accessions of related species showed another novel profile (type 4). The major anthocyanins were identified as delphinidin 3-(p-coumaroylrutinoside)-5-glucoside (nasunin) (type 1), delphinidin 3-rutinoside (type 2), delphinidin 3-glucoside (type 3), and petunidin 3-(p-coumaroylrutinoside)-5-glucoside (petunidin 3RGc5G) (type 4). Delphinidin 3-caffeoylrutinoside-5-glucoside (delphinidin 3RGcaf5G) was isolated from the hybrid (F1) plants of a type 1 cultivar and a type 3 germplasm. Among the five purified anthocyanins, delphinidin 3RGcaf5G showed the highest radical-scavenging activities toward both 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and linoleic acid radical, followed in order by nasunin and petunidin 3RGc5G.
http://pubs.acs.org/doi/abs/10.1021/jf050796r
Antiangiogenic Activity of Nasunin, an Antioxidant Anthocyanin, in Eggplant Peels
J. Agric. Food Chem., 2005, 53 (16), pp 6272–6275
DOI: 10.1021/jf050796r
Publication Date (Web): July 7, 2005
Abstract
Nasunin, delphinidin-3-(p-coumaroylrutinoside)-5-glucoside, an antioxidant anthocyanin isolated from eggplant peels, was demonstrated as an angiogenesis inhibitor. Nasunin at higher 10 μM suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring. The effect of nasunin was examined in various in vitro angiogenesis models using human umbilical vein endothelial cells (HUVECs). Nasunin suppressed HUVEC proliferation in a dose-dependent manner (50−200 μM); however, it had no significant effect on HUVEC chemotaxis in a Boyden chamber assay and HUVEC tube formation on a reconstituted basement membrane. These results imply that nasunin with both antioxidant and antiangiogenic activities might be useful to prevent angiogenesis-related diseases.
http://pubs.acs.org/doi/abs/10.1021/jf801322m
Structures and Antioxidant Activity of Anthocyanins in Many Accessions of Eggplant and Its Related Species
J. Agric. Food Chem., 2008, 56 (21), pp 10154–10159
DOI: 10.1021/jf801322m
Publication Date (Web): October 3, 2008
Abstract
Anthocyanins were detected in extracts from the peels of 123 accessions of eggplant (Solanum melongena) and its related species. Their anthocyanin profiles were classified into four types, including known Japanese eggplant type (type 1) and non-Japanese eggplant type (type 2). Although most of the eggplant accessions had one of the two known profiles, one accession had a novel profile (type 3). Two accessions of related species showed another novel profile (type 4). The major anthocyanins were identified as delphinidin 3-(p-coumaroylrutinoside)-5-glucoside (nasunin) (type 1), delphinidin 3-rutinoside (type 2), delphinidin 3-glucoside (type 3), and petunidin 3-(p-coumaroylrutinoside)-5-glucoside (petunidin 3RGc5G) (type 4). Delphinidin 3-caffeoylrutinoside-5-glucoside (delphinidin 3RGcaf5G) was isolated from the hybrid (F1) plants of a type 1 cultivar and a type 3 germplasm. Among the five purified anthocyanins, delphinidin 3RGcaf5G showed the highest radical-scavenging activities toward both 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and linoleic acid radical, followed in order by nasunin and petunidin 3RGc5G.
http://pubs.acs.org/doi/abs/10.1021/jf051841y
Nasunin from Eggplant Consists of Cis−Trans Isomers of Delphinidin 3-[4-(p-Coumaroyl)-l-rhamnosyl (1→6)glucopyranoside]-5-glucopyranoside
J. Agric. Food Chem., 2005, 53 (24), pp 9472–9477
DOI: 10.1021/jf051841y
Publication Date (Web): November 1, 2005
Abstract
Two major anthocyanins were isolated from the acidified methanolic extract of eggplant (Solanum melongena L.) by column chromatography and preparative high-performance liquid chromatography. These anthocyanins were interconvertible under room light illumination condition. By means of tandem time-of-flight mass spectrometry and nuclear magnetic resonance spectroscopy, their structures were identified and elucidated as delphinidin 3-[4-(cis-p-coumaroyl)-l-rhamnosyl(1→6)glucopyranoside]-5-glucopyranoside (compound 1) and delphinidin 3-[4-(trans-p-coumaroyl)-l-rhamnosyl-(1→6)glucopyranoside]-5-glucopyranoside (compound 2), respectively. The results indicated that nasunin comprised cis and trans isomers of the p-coumaric acid moiety in its structure.
I hope the above information is not too "confusing" for you as per your post. While it is uplifting to see the support for each other for what you are all going through or have gone through in this blog, it is also depressing to see that it appears that all the participants just sit there letting their oncologist do whatever without realising that beating cancer is a team effort between the oncologist and the patient. There are a lot you can do to not only effect a better outcome and suffer less side effects but also to maxomize the chance that the cancer does not returm. Here we are talking about your life style, your diet, supplements of vitamins, antioxidants as well as spices especially curcumin as I had posted earlier. More so is that when you are proactive doing your part and empowering yourself to be responsible for your health and to fight the cancer you don't feel as helpless and depressed as opposed to just sitting there "taking it" which will make for a less optimum outcome. Your emotional and psychological well being DOES affect the progress and outcome of yout treatment. Don't take my word for it. Ask your doctor!
Good luck to you all and good bye.
Dennis (melanomabegone)
-
- December 13, 2011 at 8:35 pm
Went to see my dermatologist a week ago ago to check up on 2 spots on my back. He took one look at what I was treating and wanted to take it out. Since it had been so much smaller I let him do it. Pathology came back yesterday that there was no invasion into the underlying layer and a lot of apoptosis, meaning cell death. My dermatologist said he had the pathologist specially look out for it after I told him what and why I was doing. Apparently the pathologist remarked that there was an "unusually high degree of apoptosis" compared to what he usually see. I am continuing my sodium bicarbonate and iodine (aqueous base) for another round to make sure nothing comes back as they normally do with surgery.
-
- December 13, 2011 at 8:35 pm
Went to see my dermatologist a week ago ago to check up on 2 spots on my back. He took one look at what I was treating and wanted to take it out. Since it had been so much smaller I let him do it. Pathology came back yesterday that there was no invasion into the underlying layer and a lot of apoptosis, meaning cell death. My dermatologist said he had the pathologist specially look out for it after I told him what and why I was doing. Apparently the pathologist remarked that there was an "unusually high degree of apoptosis" compared to what he usually see. I am continuing my sodium bicarbonate and iodine (aqueous base) for another round to make sure nothing comes back as they normally do with surgery.
-
- December 13, 2011 at 8:35 pm
Went to see my dermatologist a week ago ago to check up on 2 spots on my back. He took one look at what I was treating and wanted to take it out. Since it had been so much smaller I let him do it. Pathology came back yesterday that there was no invasion into the underlying layer and a lot of apoptosis, meaning cell death. My dermatologist said he had the pathologist specially look out for it after I told him what and why I was doing. Apparently the pathologist remarked that there was an "unusually high degree of apoptosis" compared to what he usually see. I am continuing my sodium bicarbonate and iodine (aqueous base) for another round to make sure nothing comes back as they normally do with surgery.
-
