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Paladium

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      Paladium
      Participant

        Hi Mat,

        Had the same reaction after the first dose of Ipilimumab. Most probably due to the antihistamine that was administered before that infusion. Tiredness, a strong appetite and 24 hours later a severe fever I had so surppress with paracetamol.  Next morning it was gone.

        Ben

        Paladium
        Participant

          Hi Mat,

          Had the same reaction after the first dose of Ipilimumab. Most probably due to the antihistamine that was administered before that infusion. Tiredness, a strong appetite and 24 hours later a severe fever I had so surppress with paracetamol.  Next morning it was gone.

          Ben

          Paladium
          Participant

            Hi Mat,

            Had the same reaction after the first dose of Ipilimumab. Most probably due to the antihistamine that was administered before that infusion. Tiredness, a strong appetite and 24 hours later a severe fever I had so surppress with paracetamol.  Next morning it was gone.

            Ben

            Paladium
            Participant

              Hi Rick,

              I'm sorry to hear things are getting this complicated. The only thing that comes to mind is to give the inhibitors another shot at it while looking out for a chance to participate in a panRAF trial.

              Keep the faith,

              Ben

              Paladium
              Participant

                Hi Rick,

                I'm sorry to hear things are getting this complicated. The only thing that comes to mind is to give the inhibitors another shot at it while looking out for a chance to participate in a panRAF trial.

                Keep the faith,

                Ben

                Paladium
                Participant

                  Hi Rick,

                  I'm sorry to hear things are getting this complicated. The only thing that comes to mind is to give the inhibitors another shot at it while looking out for a chance to participate in a panRAF trial.

                  Keep the faith,

                  Ben

                  Paladium
                  Participant

                    Hello everyone,

                    Seems like surgery is viable option.
                    PETCT scan from last week showed no new lesions. Known tumors in the upper leg region didn't show any signs of activity.

                    Surgeon seems confident tumor in abdomen is resectable. Depending on actual situation after opening the abdomen he will try to locate and remove other lesions which are labeled suspect.

                    All in all I'm very happy with the idea that a potentially curative intervention is within reach.

                    Ben

                    Paladium
                    Participant

                      Hello everyone,

                      Seems like surgery is viable option.
                      PETCT scan from last week showed no new lesions. Known tumors in the upper leg region didn't show any signs of activity.

                      Surgeon seems confident tumor in abdomen is resectable. Depending on actual situation after opening the abdomen he will try to locate and remove other lesions which are labeled suspect.

                      All in all I'm very happy with the idea that a potentially curative intervention is within reach.

                      Ben

                      Paladium
                      Participant

                        Hello everyone,

                        Seems like surgery is viable option.
                        PETCT scan from last week showed no new lesions. Known tumors in the upper leg region didn't show any signs of activity.

                        Surgeon seems confident tumor in abdomen is resectable. Depending on actual situation after opening the abdomen he will try to locate and remove other lesions which are labeled suspect.

                        All in all I'm very happy with the idea that a potentially curative intervention is within reach.

                        Ben

                        Paladium
                        Participant

                          Hello Sarah,

                           

                          Have been on this combo for about 12 months. After 2 months severe fevers forced me to quit Dabrafenib for a week. Within 3 days (the usual wash-out time) temperatures where back to normal.

                          For the rest of hat year I took 1000mg paracetamol 1hour before the morning and evening dose of Dabrafenib and another 1000mg in the afternoon. In spite of the paracetamol I had to quit twice for 3 days during the last month of the inhibitor therapy.

                          In my case there where no dosage adjustments considered and I could very well live with the idea to keep the chemical pressure as high as possible in order to keep maximum tumorcontrol.

                          From what I've read about it dosage adjusment will work. Even adjusting the schedule (one day on, one day off) is a way to avoid unbearable side effects. See: http://forum.melanomainternational.org/mif/viewtopic.php?f=54&t=35295

                          Good luck,

                          Ben

                           

                          Paladium
                          Participant

                            Hello Sarah,

                             

                            Have been on this combo for about 12 months. After 2 months severe fevers forced me to quit Dabrafenib for a week. Within 3 days (the usual wash-out time) temperatures where back to normal.

                            For the rest of hat year I took 1000mg paracetamol 1hour before the morning and evening dose of Dabrafenib and another 1000mg in the afternoon. In spite of the paracetamol I had to quit twice for 3 days during the last month of the inhibitor therapy.

                            In my case there where no dosage adjustments considered and I could very well live with the idea to keep the chemical pressure as high as possible in order to keep maximum tumorcontrol.

                            From what I've read about it dosage adjusment will work. Even adjusting the schedule (one day on, one day off) is a way to avoid unbearable side effects. See: http://forum.melanomainternational.org/mif/viewtopic.php?f=54&t=35295

                            Good luck,

                            Ben

                             

                            Paladium
                            Participant

                              Hello Sarah,

                               

                              Have been on this combo for about 12 months. After 2 months severe fevers forced me to quit Dabrafenib for a week. Within 3 days (the usual wash-out time) temperatures where back to normal.

                              For the rest of hat year I took 1000mg paracetamol 1hour before the morning and evening dose of Dabrafenib and another 1000mg in the afternoon. In spite of the paracetamol I had to quit twice for 3 days during the last month of the inhibitor therapy.

                              In my case there where no dosage adjustments considered and I could very well live with the idea to keep the chemical pressure as high as possible in order to keep maximum tumorcontrol.

                              From what I've read about it dosage adjusment will work. Even adjusting the schedule (one day on, one day off) is a way to avoid unbearable side effects. See: http://forum.melanomainternational.org/mif/viewtopic.php?f=54&t=35295

                              Good luck,

                              Ben

                               

                              Paladium
                              Participant

                                Hi Ray,

                                Please take a look over here : http://www.melanoma.org/find-support/patient-community/mpip-melanoma-patients-information-page/jane-pattens-touted-perseus

                                To me this sounds to good to be true. And usually that's what it turns out to be.

                                I sincerely hope the god you are reffering to isn't the god I have in mind when I read about this kind of claims.

                                Ben

                                Paladium
                                Participant

                                  Hi Ray,

                                  Please take a look over here : http://www.melanoma.org/find-support/patient-community/mpip-melanoma-patients-information-page/jane-pattens-touted-perseus

                                  To me this sounds to good to be true. And usually that's what it turns out to be.

                                  I sincerely hope the god you are reffering to isn't the god I have in mind when I read about this kind of claims.

                                  Ben

                                  Paladium
                                  Participant

                                    Hi Ray,

                                    Please take a look over here : http://www.melanoma.org/find-support/patient-community/mpip-melanoma-patients-information-page/jane-pattens-touted-perseus

                                    To me this sounds to good to be true. And usually that's what it turns out to be.

                                    I sincerely hope the god you are reffering to isn't the god I have in mind when I read about this kind of claims.

                                    Ben

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