Steph8483

I finally got my hands on the pathology report!! I have no idea what it means, so we're waiting on a call back from the doctor. Here's what it says:

Melanoma, Invasive, Nodular Type

Clark Level IV at least (base transected)

Breslow Thickness 1.8mm at least (base transected)

Vertical (tumorigenic) Growth Phase, Present

Mitotic Figures/MM2, 6

Ulceration, Not Identified

Regression, Not Identified

Vascular Invasion, Please see addendum report

Perineural Invasion, not identified

Tumor-Infiltrating Lymphocytes, Non-Brisk

Associated Melanocytic Nevus, Not Identified

Predominant Cytology, Epithelioid with Spitz Features

Surgical Margins: Melanoma Present at Deep Tissue Edge

 

Immunohistochemical students performed by the outside institution and provided to UTMDACC for review reveal patchy immunoreactivity for HMB-45 and an increase proliferative rate measured by Ki-67 (patchy labeling throughout the dermis and up to greater than 10% in some areas). PAS stain is negative for fungal organisms.

Florescence in situ hybridization (FISH) analysis with four probe set (RREB1, RREB1:CEN6 ratio, MYP:CEN6 ratio, CCND1) performed at NeoGemomics Labratories (FSG13-434) exhibited signal patterns within normal ranges. In NeoGenomics validation series, 16% of melanomas showed a negative result using the above probe set.

The histologic and immunohistochemical findings support the above diagnosis.

This case was studied and discussed at the dermatopathology faculty conference.

The following material is selected for biomarker testing: Primary. Tumor Block: A

 

 

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Any help??

I finally got my hands on the pathology report!! I have no idea what it means, so we're waiting on a call back from the doctor. Here's what it says:

Melanoma, Invasive, Nodular Type

Clark Level IV at least (base transected)

Breslow Thickness 1.8mm at least (base transected)

Vertical (tumorigenic) Growth Phase, Present

Mitotic Figures/MM2, 6

Ulceration, Not Identified

Regression, Not Identified

Vascular Invasion, Please see addendum report

Perineural Invasion, not identified

Tumor-Infiltrating Lymphocytes, Non-Brisk

Associated Melanocytic Nevus, Not Identified

Predominant Cytology, Epithelioid with Spitz Features

Surgical Margins: Melanoma Present at Deep Tissue Edge

 

Immunohistochemical students performed by the outside institution and provided to UTMDACC for review reveal patchy immunoreactivity for HMB-45 and an increase proliferative rate measured by Ki-67 (patchy labeling throughout the dermis and up to greater than 10% in some areas). PAS stain is negative for fungal organisms.

Florescence in situ hybridization (FISH) analysis with four probe set (RREB1, RREB1:CEN6 ratio, MYP:CEN6 ratio, CCND1) performed at NeoGemomics Labratories (FSG13-434) exhibited signal patterns within normal ranges. In NeoGenomics validation series, 16% of melanomas showed a negative result using the above probe set.

The histologic and immunohistochemical findings support the above diagnosis.

This case was studied and discussed at the dermatopathology faculty conference.

The following material is selected for biomarker testing: Primary. Tumor Block: A

 

 

——-

 

Any help??

I finally got my hands on the pathology report!! I have no idea what it means, so we're waiting on a call back from the doctor. Here's what it says:

Melanoma, Invasive, Nodular Type

Clark Level IV at least (base transected)

Breslow Thickness 1.8mm at least (base transected)

Vertical (tumorigenic) Growth Phase, Present

Mitotic Figures/MM2, 6

Ulceration, Not Identified

Regression, Not Identified

Vascular Invasion, Please see addendum report

Perineural Invasion, not identified

Tumor-Infiltrating Lymphocytes, Non-Brisk

Associated Melanocytic Nevus, Not Identified

Predominant Cytology, Epithelioid with Spitz Features

Surgical Margins: Melanoma Present at Deep Tissue Edge

 

Immunohistochemical students performed by the outside institution and provided to UTMDACC for review reveal patchy immunoreactivity for HMB-45 and an increase proliferative rate measured by Ki-67 (patchy labeling throughout the dermis and up to greater than 10% in some areas). PAS stain is negative for fungal organisms.

Florescence in situ hybridization (FISH) analysis with four probe set (RREB1, RREB1:CEN6 ratio, MYP:CEN6 ratio, CCND1) performed at NeoGemomics Labratories (FSG13-434) exhibited signal patterns within normal ranges. In NeoGenomics validation series, 16% of melanomas showed a negative result using the above probe set.

The histologic and immunohistochemical findings support the above diagnosis.

This case was studied and discussed at the dermatopathology faculty conference.

The following material is selected for biomarker testing: Primary. Tumor Block: A

 

 

——-

 

Any help??

The doctor’s office called and said they have a preliminary report from MD Anderson, and that they believe its “melanoma in situ” and that surgery should be enough to take care of it. I don’t really understand, because when I googled melanoma in situ it describes a brown flat mole – my son’s was pinkish and raised up off the skin. They told us the report was just prelim and could change, but I don’t think they would have called us with any info if they thought it’d be changing, you know?

The doctor’s office called and said they have a preliminary report from MD Anderson, and that they believe its “melanoma in situ” and that surgery should be enough to take care of it. I don’t really understand, because when I googled melanoma in situ it describes a brown flat mole – my son’s was pinkish and raised up off the skin. They told us the report was just prelim and could change, but I don’t think they would have called us with any info if they thought it’d be changing, you know?

The doctor’s office called and said they have a preliminary report from MD Anderson, and that they believe its “melanoma in situ” and that surgery should be enough to take care of it. I don’t really understand, because when I googled melanoma in situ it describes a brown flat mole – my son’s was pinkish and raised up off the skin. They told us the report was just prelim and could change, but I don’t think they would have called us with any info if they thought it’d be changing, you know?

Thanks for checking on us! We still are waiting to hear results. I called the pathology dept at MD Anderson and they are waiting on results from the FISH analysis – which is what I was hoping they would do. The rest of the report is done and “pending final review.” They said they ordered the materials on the 7th, and had the local pathologist here send them the rest of my son’s slides. Not sure if that’s a good thing or not? I keep telling myself no news is good news…but I’m not so sure if that’s true! How are you guys doing?

Thanks for checking on us! We still are waiting to hear results. I called the pathology dept at MD Anderson and they are waiting on results from the FISH analysis – which is what I was hoping they would do. The rest of the report is done and “pending final review.” They said they ordered the materials on the 7th, and had the local pathologist here send them the rest of my son’s slides. Not sure if that’s a good thing or not? I keep telling myself no news is good news…but I’m not so sure if that’s true! How are you guys doing?

Thanks for checking on us! We still are waiting to hear results. I called the pathology dept at MD Anderson and they are waiting on results from the FISH analysis – which is what I was hoping they would do. The rest of the report is done and “pending final review.” They said they ordered the materials on the 7th, and had the local pathologist here send them the rest of my son’s slides. Not sure if that’s a good thing or not? I keep telling myself no news is good news…but I’m not so sure if that’s true! How are you guys doing?

I called and left a message to fax the report – of *course* they're in another office today. I'm hoping the docs at MD Anderson can come up with an answer pretty quick. I'm wondering if the "materials" they had to order were for the FISH analysis? I'm really curious to find out exactly what the experts think, ya know? And we worry because we're moms 😉

I called and left a message to fax the report – of *course* they're in another office today. I'm hoping the docs at MD Anderson can come up with an answer pretty quick. I'm wondering if the "materials" they had to order were for the FISH analysis? I'm really curious to find out exactly what the experts think, ya know? And we worry because we're moms 😉

I called and left a message to fax the report – of *course* they're in another office today. I'm hoping the docs at MD Anderson can come up with an answer pretty quick. I'm wondering if the "materials" they had to order were for the FISH analysis? I'm really curious to find out exactly what the experts think, ya know? And we worry because we're moms 😉

So glad I found you guys! My son had bump removed on 12/12; we got the call exactly a week later (12/19) that it was being sent off. At first they were going to send it to the University of Florida (we live in the Florida panhandle), but the head pathologist decided to send it to MD Anderson instead. MD Anderson confirmed receipt on 12/31, and they typed an initial report on 1/2. The report is currently "on hold" because the doctor hasn't finalized it yet. On 1/7 (I'm sure I'm driving them crazy!) they ordered "more materials" so they could study it further. I'm wondering if that's the FISH analysis I've been reading about?

I feel like nobody here locally knows what's going on, and I'm reading so many conflicting things online. They haven't mentioned doing a lymph node biopsy – and everything online is 50/50, some saying it was performed & others saying it was unnecessary. The local derm told us it was atypical spitz, but when I asked her to read the report to me, the pathologist noted it was "melanoma with features of atypical spitz nevus" – to me, there's a BIG difference between "melanoma with atypical spitz features" and "atypical spitz with melanoma features"! Is it cancer or is it not cancer? There's a big difference!!

I'm also concerned because the spot is on his face, and I don't know how much tissue they'll have to remove. They did say a plastic surgeon would be there & so the scarring would hopefully be minimal. I think in my head I'm just automatically assuming the worst.

So glad I found you guys! My son had bump removed on 12/12; we got the call exactly a week later (12/19) that it was being sent off. At first they were going to send it to the University of Florida (we live in the Florida panhandle), but the head pathologist decided to send it to MD Anderson instead. MD Anderson confirmed receipt on 12/31, and they typed an initial report on 1/2. The report is currently "on hold" because the doctor hasn't finalized it yet. On 1/7 (I'm sure I'm driving them crazy!) they ordered "more materials" so they could study it further. I'm wondering if that's the FISH analysis I've been reading about?

I feel like nobody here locally knows what's going on, and I'm reading so many conflicting things online. They haven't mentioned doing a lymph node biopsy – and everything online is 50/50, some saying it was performed & others saying it was unnecessary. The local derm told us it was atypical spitz, but when I asked her to read the report to me, the pathologist noted it was "melanoma with features of atypical spitz nevus" – to me, there's a BIG difference between "melanoma with atypical spitz features" and "atypical spitz with melanoma features"! Is it cancer or is it not cancer? There's a big difference!!

I'm also concerned because the spot is on his face, and I don't know how much tissue they'll have to remove. They did say a plastic surgeon would be there & so the scarring would hopefully be minimal. I think in my head I'm just automatically assuming the worst.

So glad I found you guys! My son had bump removed on 12/12; we got the call exactly a week later (12/19) that it was being sent off. At first they were going to send it to the University of Florida (we live in the Florida panhandle), but the head pathologist decided to send it to MD Anderson instead. MD Anderson confirmed receipt on 12/31, and they typed an initial report on 1/2. The report is currently "on hold" because the doctor hasn't finalized it yet. On 1/7 (I'm sure I'm driving them crazy!) they ordered "more materials" so they could study it further. I'm wondering if that's the FISH analysis I've been reading about?

I feel like nobody here locally knows what's going on, and I'm reading so many conflicting things online. They haven't mentioned doing a lymph node biopsy – and everything online is 50/50, some saying it was performed & others saying it was unnecessary. The local derm told us it was atypical spitz, but when I asked her to read the report to me, the pathologist noted it was "melanoma with features of atypical spitz nevus" – to me, there's a BIG difference between "melanoma with atypical spitz features" and "atypical spitz with melanoma features"! Is it cancer or is it not cancer? There's a big difference!!

I'm also concerned because the spot is on his face, and I don't know how much tissue they'll have to remove. They did say a plastic surgeon would be there & so the scarring would hopefully be minimal. I think in my head I'm just automatically assuming the worst.